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PMID: 291916 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Comparison of amino acid sequence of bovine coagulation Factor IX (Christmas Factor) with that of other vitamin K-dependent plasma proteins.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 10 ·1979-10-00 ·Pages 4990-4

Katayama K, Ericsson LH, Enfield DL, Walsh KA, Neurath H, Davie EW, Titani K

Abstract

The amino acid sequence of bovine blood coagulation Factor IX (Christmas Factor) is presented and compared with the sequences of other vitamin K-dependent plasma proteins and pancreatic trypsinogen. The 416-residue sequence of Factor IX was determined largely by automated Edman degradation of two large segments, containing 181 and 235 residues, isolated after activating Factor IX with a protease from Russell's viper venom. Subfragments of the two segments were produced by enzymatic digestion and by chemical cleavage of methionyl, tryptophyl, and asparaginyl-glycyl bonds. Comparison of the amino acid sequences of Factor IX, Factor X, and Protein C demonstrates that they are homologous throughout. Their homology with prothrombin, however, is restricted to the amino-terminal region, which is rich in gamma-carboxyglutamic acid, and the carboxyl-terminal region, which represents the catalytic domain of these proteins and corresponds to that of pancreatic serine proteases.

MeSH Terms
Amino Acid Sequence Animals Blood Coagulation Factors Cattle Factor IX Factor X Glycoproteins Molecular Weight Pancreas/enzymology Prothrombin Trypsinogen Vitamin K
Chemicals
Blood Coagulation Factors Glycoproteins Vitamin K Prothrombin Factor IX Factor X Trypsinogen
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Katayama K
Ericsson L H
Enfield D L
Walsh K A
Neurath H
Davie E W
Titani K
References (36)
36 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.76.10.4990
Published
1979-10-00
Pages
4990-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC413064
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.76.10.4990 PMC Full Text View journal details
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