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PMID: 6333380 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't

Telomeric association of chromosomes in B-cell lymphoid leukemia.

Human genetics ·Vol. 67 ·No. 4 ·1984-00-00 ·Pages 385-90

Fitzgerald PH, Morris CM

Abstract

About 20% of leukemic bone marrow cells from each of two patients with B-cell lymphoid leukemias showed apparent translocations which appeared to be the result of telomeric association. In one patient, whole chromosomes were associated telomere to telomere in pairs; in the other patient, telomeres of whole chromosomes were associated with breakpoints located close to the proximal or distal ends of the heterochromatic band 1q12. Repeated base sequences, particularly (CA)n sequences, are believed to be the basis of telomere pairing, and likewise repeated base sequences of heterochromatin may explain the association of 1qh and telomeres. Telomeric association may be considered as a potential origin of new stable cytogenetic combinations that have a role in oncogene transposition and tumor etiology.

MeSH Terms
Adolescent Aged B-Lymphocytes/ultrastructure Base Sequence Bone Marrow/ultrastructure Chromosome Aberrations Chromosomes, Human, 1-3/ultrastructure Chromosomes, Human, 16-18/ultrastructure Female Heterochromatin/ultrastructure Humans Leukemia, Lymphoid/genetics Male Translocation, Genetic Trisomy
Chemicals
Heterochromatin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fitzgerald P H
Morris C M
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00291396
Published
1984-00-00
Pages
385-90
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00291396 View journal details
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