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PMID: 6330536 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Cellular src gene product detected in the freshwater sponge Spongilla lacustris.

Molecular and cellular biology ·Vol. 4 ·No. 6 ·1984-06-00 ·Pages 1179-81

Barnekow A, Schartl M

Abstract

Serum from Rous sarcoma virus tumor-bearing rabbits immunoprecipitated from extracts of the freshwater sponge Spongilla lacustris a tyrosine-specific protein kinase with characteristics similar to the chicken pp60c-src kinase activity. An immune competition assay confirmed the relationship between the protein from sponges and viral pp60v-src.

MeSH Terms

Animals Avian Sarcoma Viruses/genetics Genes Genes, Viral Kinetics Oncogene Protein pp60(v-src) Porifera/enzymology,genetics Protein Kinases/genetics Viral Proteins/genetics,metabolism

Chemicals

Viral Proteins Protein Kinases Oncogene Protein pp60(v-src)

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Barnekow A

Schartl M

References (13)

13 references, click to expand

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Identification of a transformation-specific antigen induced by an avian sarcoma virus.
Nature. 1977 Sep 22;269(5626):346-8 PMID: 198667
Uninfected avian cells contain RNA related to the transforming gene of avian sarcoma viruses.
Cell. 1978 Feb;13(2):371-9 PMID: 203404
Characteristics of cellular RNA related to the transforming gene of avian sarcoma viruses.
Cell. 1978 Feb;13(2):381-6 PMID: 203405
Protein kinase activity associated with the avian sarcoma virus src gene product.
Proc Natl Acad Sci U S A. 1978 Apr;75(4):2021-4 PMID: 205879
Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates.
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4102-6 PMID: 212733
Src Gene product from different strains of avian sarcoma virus: Kinetics and possible mechanism of heat inactivation of protein kinase activity from cells infected by transformation-defective, temperature-sensitive mutant and wild-type virus.
Proc Natl Acad Sci U S A. 1979 Feb;76(2):967-71 PMID: 218225
Cellular information in the genome of recovered avian sarcoma virus directs the synthesis of transforming protein.
Proc Natl Acad Sci U S A. 1979 Jul;76(7):3154-8 PMID: 226955
Transforming gene product of Rous sarcoma virus phosphorylates tyrosine.
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1311-5 PMID: 6246487
Molecular cloning and characterization of avian sarcoma virus circular DNA molecules.
J Virol. 1980 Oct;36(1):50-61 PMID: 6255214
Fibronectin-like protein in Porifera: its role in cell aggregation.
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6261-5 PMID: 7031644
DNA sequences homologous to vertebrate oncogenes are conserved in Drosophila melanogaster.
Proc Natl Acad Sci U S A. 1981 Nov;78(11):6789-92 PMID: 6796966
The expression in eukaryotes of a tyrosine kinase which is reactive with pp60v-src antibodies.
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Article Info

Journal

Molecular and cellular biology

Abbr.

Mol Cell Biol

ISSN

0270-7306

DOI

10.1128/mcb.4.6.1179-1181.1984

Published

1984-06-00

Pages

1179-81

Language

English

Region

United States

NLM ID

8109087

PMCID

PMC368890

Subset

External Links

PubMed source DOI: 10.1128/mcb.4.6.1179-1181.1984 PMC Full Text View journal details

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Cellular src gene product detected in the freshwater sponge Spongilla lacustris.

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