Abstract
The present study was designed to examine the effect of Pseudomonas aeruginosa alkaline protease and elastase on human polymorphonuclear leukocyte chemiluminescence. Both a luminol-enhanced and a nonenhanced chemiluminescence system using opsonized zymosan were utilized. It was found that alkaline protease and elastase at concentrations of 25 micrograms/ml strongly inhibited luminol-enhanced myeloperoxidase-mediated chemiluminescence, whereas inhibition of the nonenhanced chemiluminescence response was about 50%. In an attempt to determine the mechanism of inhibition of neutrophil chemiluminescence by these proteases, we examined the effect of various inhibitors of neutrophil oxidative metabolism on chemiluminescence, namely, superoxide dismutase, sodium azide, and catalase. It was shown that the pattern of inhibition of chemiluminescence by alkaline protease and elastase was similar to that of sodium azide, inhibitor of myeloperoxidase. The present study demonstrates that alkaline protease and elastase, extracellular products of P. aeruginosa, are capable of inhibiting myeloperoxidase-mediated chemiluminescence, one of the major antimicrobial systems of polymorphonuclear leukocytes. These findings provide further evidence for the role of P. aeruginosa exoproteases as virulence factors in the pathogenesis of infections caused by this microorganism.
MeSH Terms
Azides/pharmacology
Catalase/metabolism
Endopeptidases/metabolism
Humans
Luminescent Measurements
Luminol/pharmacology
Neutrophils/physiology
Pancreatic Elastase/metabolism
Peroxidase/blood
Pseudomonas aeruginosa/enzymology
Serine Endopeptidases
Sodium Azide
Superoxide Dismutase/metabolism
Chemicals
Azides
Luminol
Sodium Azide
Catalase
Peroxidase
Superoxide Dismutase
Endopeptidases
Serine Endopeptidases
Pancreatic Elastase
microbial serine proteinases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kharazmi A
Høiby N
Döring G
Valerius N H
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