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PMID: 6325579 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Analysis of sodium current fluctuations in the cut-open squid giant axon.

The Journal of general physiology ·Vol. 83 ·No. 2 ·1984-02-00 ·Pages 133-42

Llano I, Bezanilla F

Abstract

Patch pipettes were used to record the current arising from small populations of sodium channels in voltage-clamped cut-open squid axons. The current fluctuations associated with the time-variant sodium conductance were analyzed with nonstationary statistical techniques in order to obtain an estimate for the conductance of a single sodium channel. The results presented support the notion that the open sodium channel in the squid axon has only one value of conductance, 3.5 pS.

MeSH Terms
Animals Axons/metabolism Decapodiformes/metabolism Electrophysiology Ion Channels/metabolism Rats Sodium/metabolism
Chemicals
Ion Channels Sodium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Llano I
Bezanilla F
References (11)
11 references, click to expand
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    Proc Natl Acad Sci U S A. 1980 Dec;77(12):7484-6 PMID: 6938988
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    J Physiol. 1981 Feb;311:289-305 PMID: 6267254
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    Pflugers Arch. 1981 Aug;391(2):85-100 PMID: 6270629
  8. Currents recorded through small areas of squid axon membrane with an internal virtual ground voltage clamp.
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  9. Fluctuation of Na and K currents in excitable membranes.
    Int Rev Neurobiol. 1982;23:35-67 PMID: 6288607
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    Proc Natl Acad Sci U S A. 1982 Nov;79(21):6732-6 PMID: 6292915
  11. Sodium and calcium channels in bovine chromaffin cells.
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Article Info
Journal
The Journal of general physiology
Abbr.
J Gen Physiol
ISSN
0022-1295
DOI
10.1085/jgp.83.2.133
Published
1984-02-00
Pages
133-42
Language
English
Region
United States
NLM ID
2985110R
PMCID
PMC2215630
Subset
IM
Grants
NIGMS NIH HHS · GM30376 · United States
External Links
PubMed source DOI: 10.1085/jgp.83.2.133 PMC Full Text View journal details
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