Home LiteratureArticle Details
PMID: 631860 Published · ppublish English Comparative Study Journal Article

Reduced frequencies of mitomycin-C induced sister chromatid exchanges in AKR mice.

Human genetics ·Vol. 41 ·No. 1 ·1978-02-23 ·Pages 45-51

Kram D, Schneider EL

Abstract

The frequencies of base-line and Mitomycin-C (MMC) induced sister chromatid exchanges (SCE) were surveyed in four inbred strains of mice. In contrast to the C57Bl/6J, CBA/J, and A/J strains where frequencies of SCE increased linearly with increasing dose of MMC, levels of SCE were significantly lower in AKR/J mice at high MMC concentrations. At a dose of 5 mg/kg MMC, chromosomal aberrations were more frequent in bone marrow cells of AKR/J mice than in C57Bl/6J mice. These observations suggest an altered response to DNA damage in the AKR mouse strain.

MeSH Terms
Animals Bone Marrow/pathology Chromatids Chromosome Aberrations Dose-Response Relationship, Drug Male Mice Mice, Inbred AKR/genetics Mice, Inbred C57BL/genetics Mice, Inbred CBA/genetics Mitomycins
Chemicals
Mitomycins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kram D
Schneider E L
References (32)
32 references, click to expand
  1. A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes.
    Proc Natl Acad Sci U S A. 1974 Nov;71(11):4508-12 PMID: 4140506
  2. MITOMYCINS AND PORFIROMYCIN: CHEMICAL MECHANISM OF ACTIVATION AND CROSS-LINKING OF DNA.
    Science. 1964 Jul 3;145(3627):55-8 PMID: 14162693
  3. Differential chromatid staining by in vivo treatment as a mutagenicity test system.
    Nature. 1976 Apr 1;260(5550):448-9 PMID: 1256590
  4. Cytogenetic investigations in a new case of Bloom's syndrome.
    Hum Genet. 1976 Jan 28;31(1):47-52 PMID: 1248822
  5. Induction of sister chromatid exchanges by chemical mutagens and its possible relevance to DNA repair.
    Exp Cell Res. 1974 Apr;85(2):239-47 PMID: 4857154
  6. Increased incidence of sister chromatid exchanges in Rauscher leukaemia virus infected mouse embryo fibroblasts.
    Exp Cell Res. 1976 Dec;103(2):418-20 PMID: 1001369
  7. [Chromatid exchanges in human mitotic cells. BUDR Treatment and bichromatic fluorescence by aridine orange (author's transl)].
    Chromosoma. 1974;48(3):327-40 PMID: 4141297
  8. In vivo BUdR labeling of mammalian chromosomes.
    Exp Cell Res. 1976 Jul;100(2):396-9 PMID: 945773
  9. Localization of sister chromatid exchanges in human chromosomes.
    Science. 1974 Jul 5;185(4145):74-6 PMID: 4134970
  10. Familial constitutional panmyelocytopathy, Fanconi's anemia (F.A.). I. Clinical aspects.
    Semin Hematol. 1967 Jul;4(3):233-40 PMID: 6074578
  11. Induction by alkylating agents of sister chromatid exchanges and chromatid breaks in Fanconi's anemia.
    Proc Natl Acad Sci U S A. 1975 Oct;72(10):4066-70 PMID: 1060089
  12. Sister chromatid exchange as an assay for genetic damage induced by mutagen-carcinogens. II. In vitro test for compounds requiring metabolic activation.
    Mutat Res. 1976 Dec;41(2-3):343-50 PMID: 796721
  13. New Giemsa method for the differential staining of sister chromatids.
    Nature. 1974 Sep 13;251(5471):156-8 PMID: 4138930
  14. Genes which increase chromosomal instability in somatic cells and predispose to cancer.
    Prog Med Genet. 1972;8:61-101 PMID: 4557110
  15. Induction of sister chromatid exchanges by UV light and its inhibition by caffeine.
    Exp Cell Res. 1973 Dec;82(2):383-90 PMID: 4797252
  16. Differential fluorescence of sister chromatids in chicken embryos exposed to 5-bromodeoxyuridine.
    Chromosoma. 1975 Jul 21;51(3):261-7 PMID: 1149577
  17. Genetic factors in the natural history of murine leukemia virus infection: G. H. A. Clowes Memorial Lecture.
    Cancer Res. 1973 Dec;33(12):3061-8 PMID: 4357347
  18. Microfluorometric detection of deoxyribonucleic acid replication in human metaphase chromosomes.
    Proc Natl Acad Sci U S A. 1973 Dec;70(12):3395-9 PMID: 4128545
  19. Labelling of DNA and differential sister chromatid staining after BrdU treatment in vivo.
    Chromosoma. 1976 Aug 4;57(1):13-8 PMID: 60205
  20. Defective DNA repair in Fanconi's anaemia.
    Nature. 1974 Jul 19;250(463):223-5 PMID: 4851278
  21. Simple differential Giemsa staining of sister chromatids after treatment with photosensitive dyes and exposure to light and the mechanism of staining.
    Chromosoma. 1975 Dec 10;53(3):223-30 PMID: 53133
  22. Spontaneous sister chromatid exchanges detected by a BUdR-labelling method.
    Nature. 1974 Sep 6;251(5470):70-2 PMID: 4137941
  23. Analysis of sister chromatid exchange formation in vivo in mouse spermatogonia as a new test system for environmental mutagens.
    Nature. 1976 Apr 1;260(5550):449-51 PMID: 1256591
  24. Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange.
    Nature. 1975 Nov 13;258(5531):121-5 PMID: 52847
  25. Sister chromatid exchange as an assay for genetic damage induced by mutagen-carcinogens. I. In vivo test for compounds requiring metabolic activation.
    Mutat Res. 1976 Dec;41(2-3):333-42 PMID: 796720
  26. Sister chromatid exchanges induced by mutagenic carcinogens in normal and xeroderma pigmentosum cells.
    Nature. 1977 Jan 27;265(5592):347-9 PMID: 834283
  27. Sister chromatid exchanges--a sensitive assay of agents damaging human chromosomes.
    Mutat Res. 1975 Nov;30(2):273-8 PMID: 1207711
  28. Prevalence of murine C-type RNA virus group specific antigen in inbred strains of mice.
    Life Sci II. 1970 Sep 22;9(18):1071-80 PMID: 4320181
  29. Host-gene control of C-type RNA tumor virus: inheritance of the group-specific antigen of murine leukemia virus.
    Proc Natl Acad Sci U S A. 1971 Dec;68(12):3190-4 PMID: 4332013
  30. Quantitative studies of naturally occurring murine leukemia virus infection of AKR mice.
    J Exp Med. 1972 Feb 1;135(2):429-36 PMID: 4334098
  31. Chromatid exchanges in ataxia telangiectasia, Bloom syndrome, Werner syndrome, and xeroderma pigmentosum.
    Ann Hum Genet. 1976 Jul;40(1):79-86 PMID: 962324
  32. Induction of sister chromatid exchanges in chromosomes of rat kangaroo cells by tritium incorporated into DNA.
    Exp Cell Res. 1972 Oct;74(2):397-402 PMID: 4674129
Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00278870
Published
1978-02-23
Pages
45-51
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00278870 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2