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PMID: 6311093 Published · ppublish English Journal Article

Inactivation of haemolysin production in Escherichia coli by transposon insertion results in loss of virulence.

Antonie van Leeuwenhoek ·Vol. 49 ·No. 1 ·1983-04-00 ·Pages 23-30

Waalwijk C, de Graaff J

Abstract

A haemolytic E. coli strain is nephropathogenic for mice. Mutagenesis by transposon insertion resulted in mutants with altered haemolytic activity. Reduction or elimination of the haemolytic activity is accompanied with loss of virulence. It is shown that this loss of virulence is due to altered haemolytic activity and not caused by the transposon insertion itself.

MeSH Terms
DNA Transposable Elements Escherichia coli/genetics,metabolism,pathogenicity Hemolysin Proteins/biosynthesis Hemolysis Mutation Virulence
Chemicals
DNA Transposable Elements Hemolysin Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Waalwijk C
de Graaff J
References (14)
14 references, click to expand
  1. Plasmid cistrons controlling synthesis and excretion of the exotoxin alpha-haemolysin of Escherichia coli.
    Mol Gen Genet. 1979 Oct 1;175(3):343-50 PMID: 392234
  2. Effects of a single hit from the alpha hemolysin produced by Escherichia coli on the morphology of sheep erythrocytes.
    Infect Immun. 1980 Mar;27(3):988-94 PMID: 6991435
  3. Association of hemolysin production, hemagglutination of human erythrocytes, and virulence for chicken embryos of extraintestinal Escherichia coli isolates.
    Infect Immun. 1978 Apr;20(1):50-4 PMID: 352937
  4. Virulence of Escherichia coli in experimental hematogenous pyelonephritis in mice.
    Infect Immun. 1979 Jul;25(1):68-74 PMID: 383622
  5. Properties of strains of Escherichia coli isolated from a variety of sources.
    J Med Microbiol. 1975 Feb;8(1):107-11 PMID: 1092859
  6. Hemolysin plasmid coding for the virulence of a nephropathogenic Escherichia coli strain.
    Infect Immun. 1982 Jan;35(1):32-7 PMID: 7033139
  7. Etiology of pyelonephritis: further evidence associating the production of experimental pyelonephritis with hemolysis in Escherichia coli.
    J Urol. 1971 Sep;106(3):351-4 PMID: 4938270
  8. Cloned fragments of the plasmid ColV,I-K94 specifying virulence and serum resistance.
    Nature. 1979 Jun 28;279(5716):778-81 PMID: 377103
  9. Nonenteric toxins of Staphylococcus aureus.
    Microbiol Rev. 1979 Sep;43(3):320-60 PMID: 161608
  10. Rapid procedure for detection and isolation of large and small plasmids.
    J Bacteriol. 1981 Mar;145(3):1365-73 PMID: 7009583
  11. Haemolysis by urinary Escherichia coli and virulence in mice.
    J Med Microbiol. 1981 Aug;14(3):321-31 PMID: 7021838
  12. Virulence of urinary and faecal Escherichia coli in relation to serotype, haemolysis and haemagglutination.
    J Hyg (Lond). 1982 Jun;88(3):567-77 PMID: 7045221
  13. The haemolysins of Escherichia coli.
    J Pathol Bacteriol. 1963 Jan;85:197-211 PMID: 13989441
  14. On Bacillus coli Infections of the Urinary Tract, especially in Relation to Haemolytic Organisms.
    J Hyg (Lond). 1921 Oct;20(2):137-64 PMID: 20474731
Article Info
Journal
Antonie van Leeuwenhoek
Abbr.
Antonie Van Leeuwenhoek
ISSN
0003-6072
DOI
10.1007/BF00457876
Published
1983-04-00
Pages
23-30
Language
English
Region
Netherlands
NLM ID
0372625
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00457876 View journal details
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