Home LiteratureArticle Details
PMID: 6306567 Published · ppublish English Journal Article

Clustered repeat sequences in the genome of Epstein Barr virus.

Nucleic acids research ·Vol. 11 ·No. 12 ·1983-06-25 ·Pages 3919-37

Jones MD, Griffin BE

Abstract

The genome of Epstein-Barr virus is composed of unique DNA interspersed with repetitive sequences. This organization suggests that Epstein-Barr virus provides a useful model for studying the function(s) of repetitive sequences in eukaryotic chromosomes. The primary structure of two of the repeat sequences, the 3072 bp large internal repeat, or BamHI-W repeat, and a smaller 125 bp, G, C-rich NotI repeat, are presented here. Their structures and possible functions are discussed.

MeSH Terms
Base Sequence DNA Restriction Enzymes/metabolism DNA, Viral/analysis Deoxyribonuclease BamHI Deoxyribonucleases, Type II Site-Specific Herpesvirus 4, Human/genetics Repetitive Sequences, Nucleic Acid
Chemicals
DNA, Viral DNA Restriction Enzymes Deoxyribonuclease BamHI Deoxyribonucleases, Type II Site-Specific GCGGCCGC-specific type II deoxyribonucleases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jones M D
Griffin B E
References (40)
40 references, click to expand
  1. Molecular arrangement and evolution of heterochromatic DNA.
    Annu Rev Genet. 1980;14:121-44 PMID: 6260016
  2. Nucleotide sequences of the joint between the L and S segments of herpes simplex virus types 1 and 2.
    J Gen Virol. 1981 Aug;55(Pt 2):315-31 PMID: 6270266
  3. The structure and evolution of the human beta-globin gene family.
    Cell. 1980 Oct;21(3):653-68 PMID: 6985477
  4. The ovalbumin gene-sequence of putative control regions.
    Nucleic Acids Res. 1980 Jan 11;8(1):127-42 PMID: 6243777
  5. Epstein-Barr virus DNA. X. Direct repeat within the internal direct repeat of Epstein-Barr virus DNA.
    J Virol. 1981 Nov;40(2):501-7 PMID: 6275099
  6. Repeated DNA still in search of a function.
    Science. 1982 Aug 13;217(4560):621-3 PMID: 6283639
  7. Detection of autonomous replicating sequences (ars) in the genome of Epstein-Barr virus.
    Proc Natl Acad Sci U S A. 1983 Feb;80(4):1096-100 PMID: 6302669
  8. Comparison of Epstein-Barr virus strains of different origin by analysis of the viral DNAs.
    J Virol. 1980 Sep;35(3):603-18 PMID: 6252328
  9. Long internal direct repeat in Epstein-Barr virus DNA.
    J Virol. 1982 Oct;44(1):286-94 PMID: 6292491
  10. A system for shotgun DNA sequencing.
    Nucleic Acids Res. 1981 Jan 24;9(2):309-21 PMID: 6259625
  11. DNA of Epstein-Barr virus. VI. Mapping of the internal tandem reiteration.
    J Virol. 1979 Aug;31(2):315-24 PMID: 225556
  12. A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.
    Gene. 1982 Oct;19(3):269-76 PMID: 6295880
  13. SEQ: a nucleotide sequence analysis and recombination system.
    Nucleic Acids Res. 1982 Jan 11;10(1):279-94 PMID: 7063402
  14. Rapid synthesis of oligodeoxyribonucleotides VI. Efficient, mechanised synthesis of heptadecadeoxyribonucleotides by an improved solid phase phosphotriester route.
    Nucleic Acids Res. 1981 Apr 10;9(7):1691-706 PMID: 7232224
  15. Epstein-Barr virus RNA VII: size and direction of transcription of virus-specified cytoplasmic RNAs in a transformed cell line.
    Proc Natl Acad Sci U S A. 1981 Mar;78(3):1930-4 PMID: 6112750
  16. DNA of Epstein-Barr virus. V. Direct repeats of the ends of Epstein-Barr virus DNA.
    J Virol. 1979 Jun;30(3):852-62 PMID: 225546
  17. Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms.
    Science. 1968 Aug 9;161(3841):529-40 PMID: 4874239
  18. Molecular cloning of the complete Epstein-Barr virus genome as a set of overlapping restriction endonuclease fragments.
    Nucleic Acids Res. 1981 Jul 10;9(13):2999-3014 PMID: 6269068
  19. Analysis of transcription of the human Alu family ubiquitous repeating element by eukaryotic RNA polymerase III.
    Nucleic Acids Res. 1981 Dec 11;9(23):6439-56 PMID: 6275362
  20. Two distant regions of the Epstein-Barr virus genome with sequence homologies have the same orientation and involve small tandem repeats.
    EMBO J. 1982;1(1):21-6 PMID: 6325150
  21. DNA sequencing with chain-terminating inhibitors.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
  22. Bent helical structure in kinetoplast DNA.
    Proc Natl Acad Sci U S A. 1982 Dec;79(24):7664-8 PMID: 16593261
  23. Nucleotide sequence of bacteriophage lambda DNA.
    J Mol Biol. 1982 Dec 25;162(4):729-73 PMID: 6221115
  24. The three-dimensional structure of DNA.
    Annu Rev Biochem. 1982;51:395-427 PMID: 7051961
  25. Cleavage of Epstein-Barr virus DNA by restriction endonucleases EcoRI, HindIII and BamI.
    Nucleic Acids Res. 1978 Apr;5(4):1387-402 PMID: 206875
  26. A rapid alkaline extraction procedure for screening recombinant plasmid DNA.
    Nucleic Acids Res. 1979 Nov 24;7(6):1513-23 PMID: 388356
  27. Cloning and mapping of BamHi endonuclease fragments of DNA from the transforming B95-8 strain of Epstein-Barr virus.
    Proc Natl Acad Sci U S A. 1980 Jul;77(7):3860-4 PMID: 6253994
  28. The structure of the termini of the DNA of Epstein-Barr virus.
    Cell. 1979 Jul;17(3):661-71 PMID: 225039
  29. The sequences of an expressed rat alpha-tubulin gene and a pseudogene with an inserted repetitive element.
    Nature. 1982 Nov 25;300(5890):330-5 PMID: 6927856
  30. Partial purification of the Epstein-Barr virus and some properties of its DNA.
    Virology. 1970 Mar;40(3):776-9 PMID: 4314514
  31. Trans-complementable copy-number mutants of plasmid ColE1.
    Nature. 1980 Jan 10;283(5743):216-8 PMID: 7350544
  32. Organization of the Epstein-Barr virus DNA molecule. II. Fine mapping of the boundaries of the internal repeat cluster of B95-8 and identification of additional small tandem repeats adjacent to the HR-1 deletion.
    J Virol. 1982 Jul;43(1):201-12 PMID: 6286998
  33. Repetitive sequences in eukaryotic DNA and their expression.
    Annu Rev Biochem. 1982;51:813-44 PMID: 7051966
  34. Fate of virus DNA in the abortive infection of human lymphoid cell lines by Epstein-Barr virus.
    J Gen Virol. 1972 Sep;16(3):409-12 PMID: 4342824
  35. Identification and nucleotide sequences of two similar tandem direct repeats in Epstein-Barr virus DNA.
    J Virol. 1982 Dec;44(3):823-33 PMID: 6294332
  36. Sequence from early region of polyoma virus DNA containing viral replication origin and encoding small, middle and (part of) large T antigens.
    Cell. 1979 Jun;17(2):357-70 PMID: 222480
  37. A new method for sequencing DNA.
    Proc Natl Acad Sci U S A. 1977 Feb;74(2):560-4 PMID: 265521
  38. Organization of repeated regions within the Epstein-Barr virus DNA molecule.
    J Virol. 1980 Jan;33(1):507-21 PMID: 6245247
  39. Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.
    J Mol Biol. 1980 Oct 25;143(2):161-78 PMID: 6260957
  40. A computer program to search for tRNA genes.
    Nucleic Acids Res. 1980 Feb 25;8(4):817-25 PMID: 7433117
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/11.12.3919
Published
1983-06-25
Pages
3919-37
Language
English
Region
England
NLM ID
0411011
PMCID
PMC326016
Subset
IM
Databases
GENBANK
J02072, J02076
External Links
PubMed source DOI: 10.1093/nar/11.12.3919 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2