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PMID: 6305438 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A note on the reactivation of the fast sodium current in spherical clusters of embryonic chick heart cells.

Biophysical journal ·Vol. 42 ·No. 2 ·1983-05-00 ·Pages 191-4

Ebihara L, Shigeto N, Lieberman M, Johnson EA

Abstract

Reactivation of the fast sodium current in spherical clusters of embryonic chick heart cells was studied using the two-microelectrode voltage-clamp technique. The results show that there are at least two phases of reactivation. The contribution of the two phases to the overall reactivation process is highly dependent on the particular pulse protocol used to measure them.

MeSH Terms
Animals Cell Membrane/physiology Cells, Cultured Chick Embryo Electric Conductivity Electric Stimulation Heart/physiology Ion Channels/physiology Membrane Potentials Sodium/metabolism
Chemicals
Ion Channels Sodium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ebihara L
Shigeto N
Lieberman M
Johnson E A
References (12)
12 references, click to expand
  1. The influence of external potassium on the inactivation of sodium currents in the giant axon of the squid, Loligo pealei.
    J Gen Physiol. 1969 Jun;53(6):685-703 PMID: 5783008
  2. The effects of external potassium and long duration voltage conditioning on the amplitude of sodium currents in the giant axon of the squid, Loligo pealei.
    J Gen Physiol. 1969 Nov;54(5):589-606 PMID: 5346530
  3. Slow changes in membrane permeability and long-lasting action potentials in axons perfused with fluoride solutions.
    J Physiol. 1970 Dec;211(3):707-28 PMID: 5501058
  4. Slow recovery from inactivation of inward currents in mammalian myocardial fibres.
    J Physiol. 1974 Aug;240(3):703-24 PMID: 4415790
  5. [Slow sodium inactivation in Ranvier's node membrane. Role of external potassium].
    Biull Eksp Biol Med. 1973 Sep;76(9):15-9 PMID: 4544282
  6. The initial inward current in spherical clusters of chick embryonic heart cells.
    J Gen Physiol. 1980 Apr;75(4):437-56 PMID: 7381428
  7. Fast sodium current in cardiac muscle. A quantitative description.
    Biophys J. 1980 Nov;32(2):779-90 PMID: 7260301
  8. Kinetics of Na inactivation in frog atria.
    Pflugers Arch. 1971;323(2):141-57 PMID: 5101235
  9. The dual effect of membrane potential on sodium conductance in the giant axon of Loligo.
    J Physiol. 1952 Apr;116(4):497-506 PMID: 14946715
  10. Sodium current in single rat heart muscle cells.
    J Physiol. 1981 Sep;318:479-500 PMID: 7320902
  11. Ultra-slow inactivation of the ionic currents through the membrane of myelinated nerve.
    Biochim Biophys Acta. 1976 Mar 5;426(2):232-44 PMID: 1082773
  12. Slow sodium inactivation in Myxicola axons. Evidence for a second inactive state.
    Biophys J. 1976 Jul;16(7):771-8 PMID: 938717
Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
Published
1983-05-00
Pages
191-4
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1329222
Subset
IM
Grants
NHLBI NIH HHS · 2-P01-HL-12157 · United States
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