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PMID: 938717 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Slow sodium inactivation in Myxicola axons. Evidence for a second inactive state.

Biophysical journal ·Vol. 16 ·No. 7 ·1976-07-00 ·Pages 771-8

Schauf CL, Pencek TL, Davis FA

Abstract

Sodium inactivation and reactivation have been examined in voltage-clamped Myxicola axons after long-lasting membrane depolarizations produced either directly by changes in holding potential or indirectly by elevation of external K+ concentration. The results suggest the existence of a second inactivated state of the sodium channel with associated voltage-dependent rate constants at least two orders of magnitude lower than those of the fast inactivation process commonly examined. No specific influence of external [K+] on slow Na+ inactivation could be detected.

MeSH Terms
Animals Axons/physiology Electrophysiology Polychaeta Sodium/physiology
Chemicals
Sodium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Schauf C L
Pencek T L
Davis F A
References (12)
12 references, click to expand
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(76)85727-X
Published
1976-07-00
Pages
771-8
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1334899
Subset
IM
External Links
PubMed source DOI: 10.1016/S0006-3495(76)85727-X PMC Full Text View journal details
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