Home LiteratureArticle Details

PMID: 6292113 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Herpes simplex virus infection of human T-cell subpopulations.

Infection and immunity ·Vol. 38 ·No. 2 ·1982-11-00 ·Pages 795-7

Hammer SM, Carney WP, Iacoviello VR, Lowe BR, Hirsch MS

Abstract

The ability of herpes simplex virus type 1 to productively infect human T-cell subpopulations was examined. Unstimulated helper/inducer (T4+) and cytotoxic/suppressor (T8+) lymphocytes limited herpes simplex virus replication as effectively as unseparated peripheral blood T cells (T3+). Phytohemagglutinin stimulation before infection resulted in equivalently productive herpes simplex virus infections in the three cell fractions.

MeSH Terms

Adult Cell Separation Humans Lymphocyte Activation Simplexvirus/physiology T-Lymphocytes/microbiology T-Lymphocytes, Cytotoxic/microbiology T-Lymphocytes, Helper-Inducer/microbiology T-Lymphocytes, Regulatory/microbiology Virus Replication

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Hammer S M

Carney W P

Iacoviello V R

Lowe B R

Hirsch M S

References (14)

14 references, click to expand

Inhibition of mitogen- and antigen-induced lymphocyte blastogenesis by herpes simplex virus.
J Infect Dis. 1978 Oct;138(4):506-11 PMID: 213497
Cell-mediated immunity against herpes simplex induction of cytotoxic T lymphocytes.
Infect Immun. 1980 Jan;27(1):133-9 PMID: 6244225
Cellular and humoral immunity in the pathogenesis of recurrent herpes viral infections in patients with lymphoma.
J Clin Invest. 1980 Apr;65(4):869-78 PMID: 6244336
Herpes simplex virus depresses antibody production by affecting T-cell function.
Nature. 1980 Mar 13;284(5752):176-7 PMID: 6244499
Virus-lymphocyte interactions: infection of Tg and Tm subsets by measles virus.
Clin Immunol Immunopathol. 1980 Mar;15(3):502-9 PMID: 6966202
The differentiation and function of human T lymphocytes.
Cell. 1980 Apr;19(4):821-7 PMID: 6991122
Human T-cell cultures from virus-sensitized donors can mediate virus-specific and HLA-restricted cell lysis.
Nature. 1980 Aug 14;286(5774):718-20 PMID: 6251371
MHC matching shows that at least two T-cell subsets determine resistance to HSV.
Nature. 1979 Jan 4;277(5691):66-8 PMID: 233263
Different patterns of neurologic involvement with herpes simplex virus types 1 and 2: isolation of herpes simplex virus type 2 from the buffy coat of two adults with meningitis.
J Infect Dis. 1973 Apr;127(4):365-72 PMID: 4348495
Separation of blood leucocytes, granulocytes and lymphocytes.
Tissue Antigens. 1974;4(4):269-74 PMID: 4415728
Viremia with herpes simplex type 1 in adults. Four nonfatal cases, one with features of chicken pox.
Ann Intern Med. 1976 Aug;85(2):165-9 PMID: 182049
Cellular immunity and herpesvirus infections in cardiac-transplant patients.
N Engl J Med. 1977 Jun 16;296(24):1372-7 PMID: 193008
Replication of herpes simplex virus and cytomegalovirus in human leukocytes.
J Immunol. 1978 Jan;120(1):130-6 PMID: 203630
Experimental infection of subpopulations of human peripheral blood leukocytes by herpes simplex virus.
Proc Soc Exp Biol Med. 1978 Jun;158(2):263-8 PMID: 209475

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.38.2.795-797.1982

Published

1982-11-00

Pages

795-7

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC347810

Subset

Grants

NCI NIH HHS · CA 12464 · United States

NIAID NIH HHS · F32 AI 06227 · United States

External Links

PubMed source DOI: 10.1128/iai.38.2.795-797.1982 PMC Full Text View journal details

Analysis Services

Herpes simplex virus infection of human T-cell subpopulations.

Contact

WeChat Official Account