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PMID: 6244225 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Cell-mediated immunity against herpes simplex induction of cytotoxic T lymphocytes.

Infection and immunity ·Vol. 27 ·No. 1 ·1980-01-00 ·Pages 133-9

Lawman MJ, Rouse BT, Courtney RJ, Walker RD

Abstract

The conditions required for the induction of both primary cytotoxic T lymphocytes (CTL) in vivo and secondary CTL in vitro against herpes simplex virus type 1 (HSV-1)-infected cells were defined. Primary CTL responses occurred only in mice exposed to infectious HSV-1. These responses, which were shown to be mediated by T lymphocytes, peaked at 1 week and had disappeared by 2 weeks after infection. The level of primary cytotoxicity was enhanced by treatment of mice with cyclophosphamide before infection. Secondary in vitro CTL responses were more pronounced and were induced by some forms of inactivated virus as well as by infectious HSV-1. Thus, both ultraviolet light- and glutaraldehyde-inactivated preparations of HSV-1 induced CTL, but heat-inactivated and detergent-extracted antigens failed to do so. The reasons for the differing efficiency of infectious and noninfectious HSV-1 for induction of CTL are discussed.

MeSH Terms
Animals Antigens, Viral/immunology Cytotoxicity, Immunologic Female Immunity, Cellular Mice Mice, Inbred C3H/immunology Simplexvirus/immunology T-Lymphocytes/immunology
Chemicals
Antigens, Viral
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lawman M J
Rouse B T
Courtney R J
Walker R D
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32 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.27.1.133-139.1980
Published
1980-01-00
Pages
133-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC550735
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.27.1.133-139.1980 PMC Full Text View journal details
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