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PMID: 6287007 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Isolation and characterization of simian virus 40 early region deletion mutants.

Journal of virology ·Vol. 43 ·No. 1 ·1982-07-00 ·Pages 328-31

Sompayrac LM, Danna KJ

Abstract

We constructed a tsB4/dl884 double-mutant helper virus and used it to isolate two simian virus 40 early region deletion mutants that lack about half of the DNA sequences normally used to encode the large tumor antigen (T). Both mutants make a normal-sized small t antigen, but neither mutant can replicate its DNA in the absence of a T+ helper.

MeSH Terms
Antigens, Viral/genetics Antigens, Viral, Tumor Base Sequence DNA Replication DNA, Viral Genes, Viral Mutation Simian virus 40/genetics,immunology Virus Replication
Chemicals
Antigens, Viral Antigens, Viral, Tumor DNA, Viral
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sompayrac L M
Danna K J
References (14)
14 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.43.1.328-331.1982
Published
1982-07-00
Pages
328-31
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC256124
Subset
IM
Grants
NCI NIH HHS · CA-24924 · United States
External Links
PubMed source DOI: 10.1128/JVI.43.1.328-331.1982 PMC Full Text View journal details
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