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PMID: 6283521 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Sequence of galR gene indicates a common evolutionary origin of lac and gal repressor in Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 8 ·1982-04-00 ·Pages 2427-31

von Wilcken-Bergmann B, Müller-Hill B

Abstract

The nucleotide sequence of the galR gene of Escherichia coli, which codes for galactose repressor, has been determined. The subunits of gal repressor are predicted to consist of 343 residues, including the NH2-terminal methionine. Twenty-six of the predicted NH2-terminal 55 residues of gal repressor are identical to the NH2-terminal residues of lac repressor. Additional homologies appear between residues 165 and 200, between residues 235 and 255, and around residue 325.

MeSH Terms
Amino Acid Sequence Base Sequence Biological Evolution DNA Restriction Enzymes Escherichia coli/genetics Genes Repressor Proteins/genetics Transcription Factors/genetics
Chemicals
Repressor Proteins Transcription Factors DNA Restriction Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
von Wilcken-Bergmann B
Müller-Hill B
References (34)
34 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.8.2427
Published
1982-04-00
Pages
2427-31
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC346211
Subset
IM
Databases
GENBANK
J01614
External Links
PubMed source DOI: 10.1073/pnas.79.8.2427 PMC Full Text View journal details
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