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PMID: 6273565 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Density-dependent regulation of cell growth: an example of a cell-cell recognition phenomenon.

The Journal of membrane biology ·Vol. 63 ·No. 1-2 ·1981-00-00 ·Pages 1-11

Lieberman MA, Glaser L

Abstract

Cell-to-cell contact can result in a variety of changes in the cell's physiology. For different cell types, this may include both the initiation as well as the cessation of cell growth and changes in the state of differentiation. This review examines in detail one such phenomenon, density-dependent inhibition of growth, which is observed with many fibroblasts in culture. Data are summarized which demonstrate that the cessation of growth at high cell density is in part a consequence of cell-to-cell contact. An approach to the study of the molecular basis of this phenomenon is presented based on the demonstration that plasma membranes, when bound to sparse growing cells, mimic contact inhibition of growth. The present status of attempts to purify plasma membrane proteins responsible for this effect are summarized, and the properties of these membrane proteins are compared to those of previously described "soluble" proteins that inhibit cellular growth.

MeSH Terms
Animals Cell Communication/drug effects Cell Division/drug effects Cell Membrane/physiology Cell Transformation, Viral Cells, Cultured Contact Inhibition Epidermal Growth Factor/pharmacology Growth Substances/pharmacology Humans Kinetics Membrane Proteins/physiology Mice Mitogens/pharmacology Peptides/pharmacology Platelet-Derived Growth Factor Simian virus 40/genetics
Chemicals
Growth Substances Membrane Proteins Mitogens Peptides Platelet-Derived Growth Factor Epidermal Growth Factor
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lieberman M A
Glaser L
References (96)
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Article Info
Journal
The Journal of membrane biology
Abbr.
J Membr Biol
ISSN
0022-2631
DOI
10.1007/BF01969440
Published
1981-00-00
Pages
1-11
Language
English
Region
United States
NLM ID
0211301
Subset
IM
Grants
NIGMS NIH HHS · GM 18905 · United States
NIGMS NIH HHS · GM 28002 · United States
PHS HHS · T32-07157 · United States
External Links
PubMed source DOI: 10.1007/BF01969440 View journal details
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