Home LiteratureArticle Details
PMID: 6269936 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

A partial view of the mechanism of insulin action.

Diabetologia ·Vol. 21 ·No. 4 ·1981-10-00 ·Pages 347-62

Denton RM, Brownsey RW, Belsham GJ

Abstract

暂无摘要

MeSH Terms
Animals Binding Sites Calcium/metabolism Carbohydrate Metabolism Cyclic AMP/metabolism Cyclic GMP/metabolism Humans Hydrogen Peroxide/metabolism Insulin/physiology Lipid Metabolism Phosphorylation Protein Kinases/metabolism Proteins/metabolism
Chemicals
Insulin Proteins Hydrogen Peroxide Cyclic AMP Protein Kinases Cyclic GMP Calcium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Denton R M
Brownsey R W
Belsham G J
References (184)
184 references, click to expand
  1. Insulin action and the regulation of hexose transport.
    Diabetes. 1980 May;29(5):399-409 PMID: 6991331
  2. Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography.
    J Clin Invest. 1979 Jun;63(6):1249-61 PMID: 447843
  3. Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase.
    Biochem J. 1980 Dec 15;192(3):897-901 PMID: 6453589
  4. Calmodulin-dependent glycogen synthase kinase.
    J Biol Chem. 1980 Sep 10;255(17):8054-6 PMID: 6251041
  5. De novo synthesis of glucokinase in hepatocytes isolated from neonatal rats.
    FEBS Lett. 1980 Feb 25;111(1):115-9 PMID: 6987080
  6. Partial purification of the D-glucose transport system in rat adipocyte plasma membranes.
    J Biol Chem. 1977 Sep 25;252(18):6554-61 PMID: 893428
  7. Fat cell protein phosphorylation. Identification of phosphoprotein-2 as ATP-citrate lyase.
    J Biol Chem. 1979 Sep 25;254(18):9232-6 PMID: 479191
  8. Stimulation of a low Km phosphodiesterase from liver by insulin and glucagon.
    J Biol Chem. 1978 Feb 10;253(3):746-57 PMID: 202597
  9. Phosphorylation and dephosphorylation of phosphorylase kinase in the perfused rat heart.
    J Biol Chem. 1979 Aug 10;254(15):7345-52 PMID: 457684
  10. Control of the fructose-6-phosphate/fructose 1,6-bisphosphate cycle in isolated hepatocytes by glucose and glucagon. Role of a low-molecular-weight stimulator of phosphofructokinase.
    Biochem J. 1980 Dec 15;192(3):887-95 PMID: 6453588
  11. Insulin control of glycogen synthesis.
    Adv Cyclic Nucleotide Res. 1978;9:425-39 PMID: 208388
  12. Anti-insulin receptor antibodies mimic the effects of insulin on the activities of pyruvate dehydrogenase and acetylCoA carboxylase and on specific protein phosphorylation in rat epididymal fat cells.
    Diabetologia. 1980 Apr;18(4):307-12 PMID: 6106613
  13. Regulation of adipose tissue lipolysis: phosphorylation of hormones sensitive lipase in intact rat adipocytes.
    FEBS Lett. 1980 Feb 25;111(1):120-4 PMID: 7358152
  14. An effect of insulin on cyclic adenosine 3':5'-monophosphate phosphodiesterase activity in fat cells.
    J Biol Chem. 1973 Oct 25;248(20):7164-70 PMID: 4355201
  15. Effects of epinephrine and insulin on phosphopeptide metabolism in adipocytes.
    J Biol Chem. 1976 Mar 10;251(5):1511-5 PMID: 176155
  16. Insulin receptor synthesis and turnover in differentiating 3T3-L1 preadipocytes.
    Proc Natl Acad Sci U S A. 1980 Jan;77(1):285-9 PMID: 6928620
  17. Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.
    Proc Natl Acad Sci U S A. 1980 May;77(5):2542-5 PMID: 6771756
  18. Characterization of a pyruvate dehydrogenase activator released by adipocyte plasma membranes in response to insulin.
    J Biol Chem. 1981 Mar 25;256(6):2894-9 PMID: 7009599
  19. Effect of epinephrine and insulin on the phosphorylation of phosphorylase phosphatase inhibitor 1 in perfused rat skeletal muscle.
    FEBS Lett. 1980 Jun 2;114(2):253-6 PMID: 6993229
  20. Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats.
    Biochem J. 1976 Nov 15;160(2):413-6 PMID: 12755
  21. Modulation of the phosphorylation state of rat liver pyruvate kinase by allosteric effectors and insulin.
    J Biol Chem. 1979 Aug 25;254(16):7855-64 PMID: 468793
  22. Effect of experimental diabetes and insulin on phosphorylation of rat liver ribosomal protein S6.
    Nature. 1976 Jan 15;259(5539):148-50 PMID: 174007
  23. Insulin-stimulated intracellular hydrogen peroxide production in rat epididymal fat cells.
    J Biol Chem. 1979 Apr 10;254(7):2214-20 PMID: 429281
  24. Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase.
    Eur J Biochem. 1980 Jun;107(2):529-37 PMID: 6772446
  25. Interactions of insulin and adrenaline with glycerol phosphate acylation processes in fat-cells from rat.
    FEBS Lett. 1976 Apr 15;64(1):36-9 PMID: 1269759
  26. Pyruvate dehydrogenase and the hormonal regulation of fat synthesis in mammalian tissues.
    Int J Biochem. 1978;9(8):545-52 PMID: 213324
  27. Hormonal control of adipose tissue lipolysis.
    Proc Nutr Soc. 1975 Dec;34(3):233-9 PMID: 174121
  28. Role of multi-site phosphorylation in regulation of pig heart pyruvate dehydrogenase phosphatase.
    FEBS Lett. 1979 Dec 15;108(2):485-8 PMID: 230091
  29. The role of calcium in insulin action. III. Calcium distribution in fat cells; its kinetics and the effects of adrenaline, insulin and procaine-HCl.
    Eur J Clin Invest. 1975 Jul 29;5(4):339-49 PMID: 1175673
  30. Use of a novel rapid preparation of fat-cell plasma membranes employing Percoll to investigate the effects of insulin and adrenaline on membrane protein phosphorylation within intact fat-cells.
    Biochem J. 1980 Nov 15;192(2):457-67 PMID: 6263255
  31. Insulin trigger, cyclic AMP-dependent activation and phosphorylation of a plasma membrane cyclic AMP phosphodiesterase.
    Nature. 1980 Aug 28;286(5776):904-6 PMID: 6251375
  32. Studies on the mechanism of insulin action: basic concepts and clinical implications.
    Diabetologia. 1977 May;13(3):177-86 PMID: 194810
  33. Hormonal regulation of lipase, phosphorylase, and glycogen synthase in adipose tissue.
    Adv Cyclic Nucleotide Res. 1975;5:549-68 PMID: 165686
  34. Acute effects of insulin on fatty acid metabolism in isolated rat hepatocytes.
    Horm Metab Res. 1980 Sep;12(9):425-30 PMID: 6107268
  35. Modulation of hydroxymethylglutaryl-CoA reductase activity, reductase kinase activity, and cholesterol synthesis in rat hepatocytes in response to insulin and glucagon.
    J Biol Chem. 1979 Oct 25;254(20):9986-9 PMID: 489617
  36. Regulation by lipolytic and antillipolytic compounds of the phosphorylation of specific proteins in isolated intact fat cells.
    Arch Biochem Biophys. 1976 Oct;176(2):721-33 PMID: 185967
  37. Studies on the insulin mediator. II. Separation of two antagonistic biologically active materials from fraction II.
    Diabetes. 1980 Aug;29(8):659-61 PMID: 6254825
  38. Chemistry of insulin; determination of the structure of insulin opens the way to greater understanding of life processes.
    Science. 1959 May 15;129(3359):1340-4 PMID: 13658959
  39. Hormonal regulation of adipocyte enzymes. The effects of epinephrine and insulin on the control of lipase, phosphorylase kinase, phosphorylase, and glycogen synthase.
    J Biol Chem. 1973 Jun 10;248(11):3823-30 PMID: 4350646
  40. Internalization of polypeptide hormones: mechanism, intracellular localization and significance.
    Diabetologia. 1980 Apr;18(4):263-74 PMID: 6998797
  41. Rat adipose-tissue glycerol phosphate acyltransferase can be inactivated by cyclic AMP-dependent protein kinase.
    Biochem J. 1978 Nov 15;176(2):607-10 PMID: 217367
  42. Reversible inhibition of cyclic AMP-dependent protein kinase by insulin.
    Mol Cell Biochem. 1978 Feb 24;19(1):31-41 PMID: 25380
  43. Rapid antagonistic actions of noradrealine and insulin on rat adipocyte phosphatidate phosphohydrolase activity.
    FEBS Lett. 1978 Sep 1;93(1):120-4 PMID: 212308
  44. Mechanisms involved in alpha-adrenergic phenomena: role of calcium ions in actions of catecholamines in liver and other tissues.
    Am J Physiol. 1980 Jan;238(1):E3-12 PMID: 6243874
  45. Insulin effect on protein phosphorylation of plasma membranes and mitochondria in a subcellular system from rat adipocytes. I. Identification of insulin-sensitive phosphoproteins.
    J Biol Chem. 1979 Aug 10;254(15):6991-6 PMID: 457665
  46. Regulation of adenosine 3',5'-monophosphate-dependent protein kinase. II. Hormonal regulation of the adipose tissue enzyme.
    J Biol Chem. 1973 Mar 10;248(5):1822-9 PMID: 4348551
  47. Insulin binding and effects in isolated soleus muscle of lean and obese mice.
    Am J Physiol. 1978 Apr;234(4):E348-58 PMID: 206148
  48. Insulin regulation of hepatic glycogen synthase and phosphorylase.
    Biochemistry. 1978 Feb 7;17(3):406-10 PMID: 413570
  49. The antilipolytic action of insulin on adrenocorticotrophin-stimulated rat adipocytes. The roles of adenosine 3',5'-monophosphate and the protein kinase dependent on adenosine 3',5'-monophosphate.
    Eur J Biochem. 1981 Mar 16;115(1):17-22 PMID: 6262080
  50. Opposite effects of insulin and glucagon in acute hormonal control of hepatic lipogenesis.
    Diabetes. 1979 Sep;28(9):828-35 PMID: 467808
  51. Effect of insulin on the phosphorylation of adipose tissue protein.
    Biochim Biophys Acta. 1974 May 10;351(1):28-41 PMID: 4365889
  52. An effect of insulin on adipose-tissue adenosine 3':5'-cyclic monophosphate phosphodiesterase.
    Biochem J. 1970 Nov;120(1):187-93 PMID: 4321931
  53. Generation by insulin of a chemical mediator that controls protein phosphorylation and dephosphorylation.
    Science. 1979 Dec 21;206(4425):1408-10 PMID: 228395
  54. Anti-insulin receptor antibodies inhibit insulin binding and stimulate glucose metabolism in skeletal muscle.
    Diabetologia. 1978 May;14(5):311-7 PMID: 648762
  55. Reduced nicotinamide adenine dinucleotide phosphate oxidase in adipocyte plasma membrane and its activation by insulin. Possible role in the hormone's effects on adenylate cyclase and the hexose monophosphate shunt.
    Arch Biochem Biophys. 1977 Nov;184(1):69-76 PMID: 21633
  56. A stimulatory effect of insulin on phosphorylation of a peptide in sarcolemma-enriched membrane preparation from rat skeletal muscle.
    FEBS Lett. 1977 Aug 15;80(2):417-22 PMID: 196937
  57. The effect of insulin and adrenaline on the phosphorylation of a 22 000-molecular weight protein within isolated fat cells; possible identification as the inhibitor-1 of the 'general phosphatase' [proceedings].
    Biochem Soc Trans. 1980 Jun;8(3):382-3 PMID: 6249675
  58. Inactivation of phosphofructokinase by glucagon in rat hepatocytes.
    J Biol Chem. 1979 Jul 10;254(13):5576-9 PMID: 156182
  59. Effects of insulin on diaphragm muscle independent of the variation of tissue levels of cyclic AMP and cyclic GMP.
    Arch Biochem Biophys. 1976 May;174(1):192-8 PMID: 180892
  60. Control of acetyl-CoA carboxylase by covalent modification.
    Mol Cell Biochem. 1979 Dec 14;28(1-3):27-43 PMID: 43470
  61. Activation of rat adipocyte glycogen synthase by insulins.
    J Biol Chem. 1977 Jan 25;252(2):444-50 PMID: 401814
  62. Multiple phosphorylation of rabbit skeletal muscle glycogen synthase. Comparison of the actions of different protein kinases capable of catalyzing phosphorylation in vitro.
    J Biol Chem. 1979 Dec 10;254(23):12062-8 PMID: 115877
  63. Evidence that fatty acid synthesis in the interscapular brown adipose tissue of cold-adapted rats is increased in vivo by insulin by mechanisms involving parallel activation of pyruvate dehydrogenase and acetyl-coenzyme A carboxylase.
    Biochem J. 1977 Sep 15;166(3):627-30 PMID: 23106
  64. Actions of insulin, epinephrine, and dibutyryl cyclic adenosine 5'-monophosphate on fat cell protein phosphorylations. Cyclic adenosine 5'-monophosphate dependent and independent mechanisms.
    Biochemistry. 1975 Jul 29;14(15):3301-9 PMID: 167823
  65. Demonstration of the phosphorylation of acetyl-coenzyme A carboxylase within intact rat epididymal fat-cells.
    Biochem J. 1977 Dec 15;168(3):441-5 PMID: 24437
  66. Characterization of the phosphorylated form of the insulin-stimulated cyclic AMP phosphodiesterase from rat liver plasma membranes.
    Biochem J. 1981 Jun 1;195(3):653-60 PMID: 6274309
  67. Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity.
    J Biol Chem. 1980 May 25;255(10):4834-42 PMID: 6246084
  68. Adrenaline and the regulation of acetyl-coenzyme A carboxylase in rat epididymal adipose tissue. Inactivation of the enzyme is associated with phosphorylation and can be reversed on dephosphorylation.
    Biochem J. 1979 Oct 15;184(1):23-32 PMID: 43140
  69. Studies on the role of cyclic guanosine 3':5'-monophosphate and extracellular Ca2+ in the regulation of glycogenolysis in rat liver cells.
    J Biol Chem. 1976 May 25;251(10):2987-92 PMID: 178660
  70. Absent pyruvate inhibition of pyruvate dehydrogenase kinase in lactating rat mammary gland following various treatments. Removal of circulating insulin and prolactin and exposure to protein synthesis inhibitors.
    FEBS Lett. 1979 Jan 1;97(1):27-31 PMID: 153847
  71. Identification and subcellular distribution of adipocyte peptides and phosphopeptides.
    J Biol Chem. 1976 Mar 10;251(5):1505-10 PMID: 1254581
  72. Regulation by insulin of adipose tissue pyruvate dehydrogenase. A mechanism controlling fatty acid synthesis from carbohydrates.
    Hoppe Seylers Z Physiol Chem. 1974 Mar;355(3):363-77 PMID: 4435728
  73. Regulation of hepatic acetyl coenzyme A carboxylase by insulin and glucagon.
    J Biol Chem. 1979 Jul 25;254(14):6644-9 PMID: 36401
  74. Insulin-stimulated glucose uptake by subcellular particles from adipose tissue cells.
    Science. 1970 Feb 6;167(3919):873-4 PMID: 5460693
  75. Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells.
    Cell. 1976 Jan;7(1):105-13 PMID: 949738
  76. Hormonal regulation of adipose-tissue acetyl-Coenzyme A carboxylase by changes in the polymeric state of the enzyme. The role of long-chain fatty acyl-Coenzyme A thioesters and citrate.
    Biochem J. 1974 Aug;142(2):365-77 PMID: 4155293
  77. Short-term effects of insulin and glucagon on lipid synthesis in isolated rat hepatocytes. Covariance of acetyl-CoA carboxylase activity and the rate of 3H2O incorporation into fatty acids.
    FEBS Lett. 1978 Nov 15;95(2):326-30 PMID: 31303
  78. Insulin-receptor antibodies mimic a late insulin effect.
    Nature. 1979 Aug 9;280(5722):500-2 PMID: 460430
  79. Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor.
    J Biol Chem. 1979 Jun 10;254(11):4884-91 PMID: 312292
  80. Action of insulin and catecholamines on the phosphorylation of proteins associated with the cytosol, membranes, and "fat cake" of rat fat cells.
    J Biol Chem. 1978 Mar 10;253(5):1700-9 PMID: 627566
  81. Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes.
    Mol Cell Biochem. 1978 Dec 22;22(2-3):153-7 PMID: 106236
  82. On the role of the calcium transport cycle in heart and other mammalian mitochondria.
    FEBS Lett. 1980 Sep 22;119(1):1-8 PMID: 7000543
  83. Phosphorylation of ATP-citrate lyase by a cyclic AMP-independent protein kinase from rat liver.
    FEBS Lett. 1981 Feb 23;124(2):140-4 PMID: 6262114
  84. Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase.
    Biochem J. 1972 Jun;128(1):161-3 PMID: 4343661
  85. The action of insulin on the distribution of galactose in eviscerated nephrectomized dogs.
    J Biol Chem. 1949 Jun;179(2):985 PMID: 18150030
  86. Triacylglycerol synthesis in isolated fat cells. An effect of insulin on microsomal fatty acid coenzyme A ligase activity.
    J Biol Chem. 1976 Mar 10;251(5):1488-92 PMID: 1254580
  87. Regulation by insulin and free fatty acids of pyruvate dehydrogenase activity in perfused rat liver [proceedings].
    Biochem Soc Trans. 1977;5(4):1000-1 PMID: 913758
  88. Control of hepatic glycogenolysis.
    Physiol Rev. 1980 Jan;60(1):1-50 PMID: 6243781
  89. GLUCOSE UPTAKE BY INCUBATED RAT EPIDIDYMAL ADIPOSE TISSUE. RATE-LIMITING STEPS AND SITE OF INSULIN ACTION.
    J Biol Chem. 1965 Jan;240:14-21 PMID: 14253407
  90. Identification of ATP citrate lyase as a phosphoprotein.
    J Biol Chem. 1979 Mar 10;254(5):1691-8 PMID: 762167
  91. Mode of insulin action.
    Lancet. 1975 Jan 18;1(7899):144-7 PMID: 46056
  92. Insulin-like effects of polyamines in fat cells. Mediation by H2O2 formation.
    J Biol Chem. 1977 Jan 25;252(2):560-2 PMID: 833144
  93. The effect of insulin on the glycogenolytic cascade and on the activity of glycogen synthase in the liver of anaesthetized rabbits.
    Biochem J. 1977 Jan 15;162(1):143-6 PMID: 192207
  94. Regulation of lipogenesis in adipose tissue: the significance of the activation of pyruvate dehydrogenase by insulin.
    Arch Biochem Biophys. 1974 Sep;164(1):12-9 PMID: 4279624
  95. Insulin-stimulated protein phosphorylation in 3T3-L1 preadipocytes.
    Proc Natl Acad Sci U S A. 1979 Jun;76(6):2725-9 PMID: 313567
  96. A decrease in diacylglycerol acyltransferase after treatment of rat adipocytes with adrenaline.
    FEBS Lett. 1978 Nov 1;95(1):85-7 PMID: 720609
  97. The regulation of glycogen metabolism. Purification and characterisation of protein phosphatase inhibitor-1 from rabbit skeletal muscle.
    Eur J Biochem. 1978 Jun 15;87(2):341-51 PMID: 208844
  98. Incorporation of [32P]phosphate into the pyruvate dehydrogenase complex in rat heart mitochondria.
    Biochem J. 1980 May 15;188(2):409-21 PMID: 7396870
  99. Norepinephrine control of endogenous polypeptide phosphorylation in white fat cells.
    FEBS Lett. 1978 Dec 1;96(1):69-74 PMID: 215453
  100. Epidermal growth factor stimulates phosphorylation in membrane preparations in vitro.
    Nature. 1978 Nov 23;276(5686):409-10 PMID: 309559
  101. Control of glycogen synthase and phosphorylase by insulin in rat adipocytes which is unrelated to the concentration of cyclic AMP.
    Biochim Biophys Acta. 1979 Feb 1;582(3):402-1 PMID: 217439
  102. Characterization of insulin-sensitive phosphodiesterase in fat cells. II. Comparison of enzyme activities stimulated by insulin and by isoproterenol.
    J Biol Chem. 1980 Aug 25;255(16):7850-4 PMID: 6249818
  103. Activation of pyruvate dehydrogenase by insulin in isolated brown fat cells.
    Horm Metab Res. 1979 Apr;11(4):285-8 PMID: 457031
  104. Evidence for phosphorylation and activation of acetyl CoA carboxylase by a membrane-associated cyclic AMP-independent protein kinase. Relationship to the activation of acetyl CoA carboxylase by insulin.
    FEBS Lett. 1981 Feb 23;124(2):145-50 PMID: 6112166
  105. The role of insulin receptors and receptor antibodies in states of altered insulin action.
    Proc Soc Exp Biol Med. 1979 Oct;162(1):13-21 PMID: 504220
  106. Activation of pyruvate dehydrogenase by direct addition of insulin to an isolated plasma membrane/mitochondria mixture: evidence for generated of insulin's second messenger in a subcellular system.
    Proc Natl Acad Sci U S A. 1980 Jan;77(1):77-81 PMID: 6987660
  107. Inhibition of the glucagon stimulated adenylate cyclase activity by insulin.
    FEBS Lett. 1978 Aug 1;92(1):29-32 PMID: 668918
  108. Protein phosphorylation in rat liver plasma membranes: in vitro and in vivo inhibition by insulin.
    FEBS Lett. 1980 Jul 28;116(2):149-53 PMID: 6250881
  109. The role of cyclic-AMP-dependent protein kinase in the regulation of glycogen metabolism in mammalian skeletal muscle.
    Curr Top Cell Regul. 1978;14 :117-96 PMID: 215384
  110. Effects of insulin on the levels of adenosine 3':5'-monophosphate and lipolysis in isolated rat epididymal fat cells.
    J Biol Chem. 1973 Nov 10;248(21):7417-26 PMID: 4355581
  111. Reconstitution of D-glucose transport activity from cytoplasmic membranes. Evidence against recruitment of cytoplasmic membrane transporters into the plasma membrane as the sole action of insulin.
    J Biol Chem. 1980 Nov 10;255(21):10382-6 PMID: 7000777
  112. Interacting actions of insulin and unesterified fatty acids on lipogenic enzymes in rat adipocytes.
    FEBS Lett. 1976 Oct 15;69(1):144-8 PMID: 992024
  113. Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.
    J Biol Chem. 1980 May 25;255(10):4758-62 PMID: 6989818
  114. Regulation of mammalian pyruvate dehydrogenase.
    Mol Cell Biochem. 1975 Oct 31;9(1):27-53 PMID: 171557
  115. Molecular basis of insulin action.
    Annu Rev Biochem. 1977;46:359-84 PMID: 197878
  116. Regulation of acetyl-CoA carboxylase: identity fo sites phosphorylated in intact cells treated with adrenaline and in vitro by cyclic AMP-dependent protein kinase.
    FEBS Lett. 1980 Oct 20;120(1):67-70 PMID: 6108241
  117. Interactions polypeptide hormones with cell membrane specific receptors: studies with insulin and glucagon.
    Diabetologia. 1976 May;12(2):83-100 PMID: 178558
  118. Studies on the incorporation of [32P]phosphate into pyruvate dehydrogenase in intact rat fat-cells. Effects of insulin.
    Biochem J. 1980 Nov 15;192(2):469-81 PMID: 7016113
  119. Hepatic pyruvate kinase. Regulation by glucagon, cyclic adenosine 3'-5'-monophosphate, and insulin in the perfused rat liver.
    J Biol Chem. 1976 Jun 25;251(12):3756-62 PMID: 180008
  120. Cyclic guanosine 3':5'-monophosphate and the regulation of lipolysis in rat fat cells.
    J Cyclic Nucleotide Res. 1976;2(2):71-8 PMID: 177466
  121. Characterization of insulin-sensitive phosphodiesterase in fat cells. I. Effects of salts and oxidation-reduction agents.
    J Biol Chem. 1980 Aug 25;255(16):7845-9 PMID: 6249817
  122. Regulatory functions of protein multisite phosphorylation.
    Mol Cell Endocrinol. 1979 Dec;16(3):157-79 PMID: 230103
  123. The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.
    N Engl J Med. 1976 Apr 1;294(14):739-45 PMID: 176581
  124. Evidence that insulin activates an intrinsic plasma membrane protease in generating a secondary chemical mediator.
    J Biol Chem. 1980 Jul 25;255(14):6529-31 PMID: 6993474
  125. Hormonal and ionic control of the glycogenolytic cascade in rat liver.
    Biochem J. 1977 Jan 15;162(1):135-42 PMID: 192206
  126. Activation of the pyruvate dehydrogenase complex in isolated fat cell mitochondria by hydrogen peroxide and t-butyl hydroperoxide.
    FEBS Lett. 1980 Dec 15;122(1):29-32 PMID: 7011843
  127. Studies on the interactions between insulin and epinephrine in the control of skeletal muscle glycogen metabolism.
    J Biol Chem. 1981 May 10;256(9):4450-4 PMID: 6260799
  128. Partial purification from rat adipocyte plasma membranes of a chemical mediator which simulates the action of insulin on pyruvate dehydrogenase.
    J Biol Chem. 1981 Mar 25;256(6):2945-51 PMID: 7009600
  129. Mechanism of insulin action on glucose transport in the isolated rat adipose cell. Enhancement of the number of functional transport systems.
    J Biol Chem. 1978 Nov 25;253(22):8002-5 PMID: 711732
  130. Studies on the mechanism of insulin-stimulated protein phosphorylation in adipocytes.
    Biochem Biophys Res Commun. 1980 Jun 30;94(4):1331-6 PMID: 6249308
  131. Insulin-treated 3T3-L1 adipocytes and cell-free extracts derived from them incorporate 32P into ribosomal protein S6.
    Proc Natl Acad Sci U S A. 1980 May;77(5):2641-5 PMID: 6156454
  132. Effect of insulin and lipolytic agents on rat adipocyte low Km cyclic adenosine 3':5'-monophosphate phosphodiesterase.
    J Biol Chem. 1974 Apr 10;249(7):2182-7 PMID: 4362065
  133. Insulin effect on protein phosphorylation of plasma membranes and mitochondria in a subcellular system from rat adipocytes. II. Characterization of insulin-sensitive phosphoproteins and conditions for observation of the insulin effect.
    J Biol Chem. 1979 Aug 10;254(15):6997-7001 PMID: 222753
  134. Inhibition by insulin of the adrenaline-stimulated adenylate cyclase in rat adipose tissue.
    FEBS Lett. 1979 Sep 1;105(1):19-22 PMID: 488342
  135. Insulin and the regulation of adipose tissue acetyl-coenzyme A carboxylase.
    Biochem J. 1973 Mar;132(3):509-17 PMID: 4146798
  136. Purification of a hepatic 123,000-dalton hormone-stimulated 32P-peptide and its identification as ATP-citrate lyase.
    J Biol Chem. 1979 Aug 25;254(16):8052-6 PMID: 468805
  137. Glucagon regulation of protein phosphorylation. Identification of acetyl coenzyme A carboxylase as a substrate.
    J Biol Chem. 1979 Jan 25;254(2):245-8 PMID: 33166
  138. Acute effects of insulin on glycerol phosphate acyl transferase activity, ketogenesis and serum free fatty acid concentration in perfused rat liver.
    FEBS Lett. 1977 Dec 15;84(2):225-8 PMID: 598501
  139. Synthesis of a stimulator of phosphofructokinase, most likely fructose 2,6-bisphosphate, from phosphoric acid and fructose 6-phosphoric acid.
    Biochem Biophys Res Commun. 1980 Oct 31;96(4):1524-31 PMID: 6449929
  140. Occupancy of sites of phosphorylation in inactive rat heart pyruvate dehydrogenase phosphate in vivo.
    Biochem J. 1981 Mar 1;193(3):935-46 PMID: 7305968
  141. Insulin stimulation of pyruvate dehydrogenase in an isolated plasma membrane-mitochondrial mixture occurs by activation of pyruvate dehydrogenase phosphatase.
    J Biol Chem. 1980 Aug 25;255(16):7540-3 PMID: 6249805
  142. Phosphorylation of glycogen synthase in the perfused rat heart.
    J Biol Chem. 1979 Aug 10;254(15):7336-44 PMID: 110808
  143. The inactivation of rat adipocyte Mg2+-dependent phosphatidate phosphohydrolase by noradrenaline.
    Biochem J. 1980 Sep 15;190(3):659-62 PMID: 6258575
  144. Studies of the effect of adrenaline on glycerol phosphate acyltransferase activity in rat adipocytes.
    FEBS Lett. 1978 Jun 1;90(1):141-4 PMID: 658430
  145. Phosphorylation of ATP citrate lyase in response to glucagon.
    J Biol Chem. 1979 Oct 10;254(19):9365-8 PMID: 489538
  146. Ca2+-stimulated phosphorylation of muscle glycogen synthase by phosphorylase b kinase.
    J Cyclic Nucleotide Res. 1978 Aug;4(4):245-57 PMID: 102668
  147. Mitochondrial calcium transport.
    FEBS Lett. 1980 Mar 10;111(2):261-8 PMID: 6987089
  148. The hormonal control of glycogen metabolism. Phosphorylation of protein phosphatase inhibitor-1 in vivo in response to adrenaline.
    Eur J Biochem. 1979 Jun;97(1):251-6 PMID: 225171
  149. Incorporation of 32Pi into pyruvate dehydrogenase phosphate in mitochondria from control and insulin-treated adipose tissue.
    Nature. 1976 Dec 2;264(5585):471-3 PMID: 187955
  150. Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated hepatocytes.
    Proc Natl Acad Sci U S A. 1976 Aug;73(8):2762-6 PMID: 183209
  151. Direct addition of insulin inhibits a high affinity Ca2+-ATPase in isolated adipocyte plasma membranes.
    Nature. 1979 Oct 11;281(5731):495-7 PMID: 158710
  152. Proteolytic solubilization and modification of hormone-sensitive cyclic nucleotide phosphodiesterase.
    J Biol Chem. 1980 Aug 25;255(16):7838-44 PMID: 6249816
  153. Acute regulation of pyruvate kinase activity in rat epididymal adipose tissue by insulin.
    Biochem J. 1979 Jun 15;180(3):523-31 PMID: 486131
  154. Hormonal regulation of cyclic-AMP-dependent protein kinase of rat diaphragm by epinephrine and insulin.
    Eur J Biochem. 1973 Dec 17;40(2):465-77 PMID: 4360898
  155. Regulation of adipose tissue lipolysis: effects of noradrenaline and insulin on phosphorylation of hormone-sensitive lipase and on lipolysis in intact rat adipocytes.
    FEBS Lett. 1980 Feb 25;111(1):125-30 PMID: 6987081
  156. Phosphorylation of additional sites on pyruvate dehydrogenase inhibits its re-activation by pyruvate dehydrogenase phosphate phosphatase.
    Biochem J. 1978 Feb 1;169(2):433-5 PMID: 204298
  157. Modulation of adenylate cyclase activity in liver and fat cell membranes by insulin.
    Science. 1972 Feb 25;175(4024):906-8 PMID: 4332823
  158. Retention of insulin-stimulated D-glucose transport activity by adipocyte plasma membranes following extraction of extrinsic proteins.
    J Supramol Struct. 1978;8(3):269-77 PMID: 723265
  159. Studies on alpha-adrenergic activation of hepatic glucose output. Insulin inhibition of alpha-adrenergic and glucagon actions in normal and calcium-depleted hepatocytes.
    J Biol Chem. 1979 Apr 25;254(8):2828-34 PMID: 218955
  160. Insulin action on the adenyl cyclase system: Antagonism to activation by lipolytic hormones.
    FEBS Lett. 1972 Feb 1;20(2):191-194 PMID: 11946413
  161. Amino acid sequences around the sites of phosphorylation in the pig heart pyruvate dehydrogenase complex.
    Biochem J. 1979 Aug 1;181(2):419-26 PMID: 496891
  162. Dephosphorylation and activation of acetyl-CoA carboxylase from lactating rabbit mammary gland.
    FEBS Lett. 1979 Jul 15;103(2):333-8 PMID: 38145
  163. Regulation of pyruvate metabolism in mammalian tissues.
    Essays Biochem. 1979;15:37-77 PMID: 391551
  164. Regulation of lipid metabolism in adipose tissue and heart.
    Can J Physiol Pharmacol. 1979 Sep;57(9):923-37 PMID: 391374
  165. The effect of insulin on the washout of [45Ca]calcium from adipocytes and soleus muscle of the rat.
    Biochem J. 1977 Apr 15;164(1):251-5 PMID: 880231
  166. Hormonal regulation of acetyl CoA carboxylase effect of insulin and epinephrine.
    Biochem Biophys Res Commun. 1973 Oct 1;54(3):1133-40 PMID: 4753188
  167. Effects of autoantibodies to the insulin receptor on isolated adipocytes. Studies of insulin binding and insulin action.
    J Clin Invest. 1977 Nov;60(5):1094-106 PMID: 908753
  168. Insulin controls the cyclic AMP-dependent phosphorylation of integral and peripheral proteins associated with the rat liver plasma membrane.
    FEBS Lett. 1980 Aug 25;118(1):18-24 PMID: 6250905
  169. Pyruvate dehydrogenase activation in adipocyte mitochondria by an insulin-generated mediator from muscle.
    Science. 1979 Dec 21;206(4425):1407-8 PMID: 505013
  170. The hormonal control of glycogen metabolism: dephosphorylation of protein phosphatase inhibitor-1 in vivo in response to insulin.
    FEBS Lett. 1980 Mar 24;112(1):21-4 PMID: 6245928
  171. Separation and characterization of two phosphorylase phosphatase inhibitors from rabbit skeletal muscle.
    Eur J Biochem. 1976 Nov 15;70(2):419-26 PMID: 188646
  172. Effects of glucagon and insulin on cytoplasmic protein phosphorylation in hepatocytes.
    J Biol Chem. 1978 Jul 10;253(13):4754-61 PMID: 659446
  173. Inactivation of rabbit muscle phosphorylase phosphatase by cyclic AMP-dependent kinas.
    Proc Natl Acad Sci U S A. 1975 Aug;72 (8):3004-8 PMID: 171649
  174. The ability of insulin to alter the stable calcium pools of isolated adipocyte subcellular fractions.
    Biochem Biophys Res Commun. 1976 Jul 12;71(1):114-21 PMID: 822846
  175. The insulin-like effect of hydrogen peroxide on pathways of lipid synthesis in rat adipocytes.
    J Biol Chem. 1979 Sep 25;254(18):9017-21 PMID: 479177
  176. Insulin-sensitive phosphodiesterase. Its localization, hormonal stimulation, and oxidative stabilization.
    J Biol Chem. 1975 Oct 10;250(19):7826-35 PMID: 170271
  177. HeLa ribosomal protein S6. Insulin and dibutyryl cyclic AMP affect different phosphopeptides.
    J Biol Chem. 1981 Jan 25;256(2):583-5 PMID: 6256361
  178. Regulation of plasma membrane protein phosphorylation in two mammalian cell types.
    J Cell Physiol. 1976 Dec;89(4):815-26 PMID: 188851
  179. Insulin activates glycogen synthase in phosphorylase kinase deficient mice.
    FEBS Lett. 1979 Sep 15;105(2):235-8 PMID: 114423
  180. The relationship between the concentration of adenosine 3':5'-cyclic monophosphate and the anti-lipolytic action of insulin in isolated rat fat-cells.
    Biochem J. 1974 Jul;142(1):97-103 PMID: 4374189
  181. The effect of insulin and guanosine nucleotides on protein phosphorylations by sarcolemma membranes from skeletal muscle.
    Mol Cell Endocrinol. 1979 Oct;16(1):45-55 PMID: 227762
  182. A dual role for insulin in the regulation of cardiac glycogen synthase.
    J Biol Chem. 1978 Aug 10;253(15):5389-94 PMID: 209039
  183. Sites of phosphorylation on pyruvate dehydrogenase from bovine kidney and heart.
    Biochemistry. 1978 Jun 13;17(12):2364-70 PMID: 678513
  184. Interactions of metabolism and the physiological role of insulin.
    Recent Prog Horm Res. 1966;22:1-48 PMID: 5334625
Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF00252681
Published
1981-10-00
Pages
347-62
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00252681 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2