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PMID: 6264468 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

A model for biological oscillations.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 4 ·1981-04-00 ·Pages 2204-7

Chay TR

Abstract

A model and computation for oscillatory phenomena observed in some biological processes that utilize ion gradients across a membrane is presented. The model contains two main features: (i) active H+ transport pathways in the membrane and (ii) key enzymes having a pH-dependent activity profile and either translocating H+ from outside or producing H+ as a product. With this model a very long period of oscillations, as observed in mitochondrial and circadian rhythms, could be quantitatively demonstrated.

MeSH Terms
Biological Transport, Active Carrier Proteins/physiology Circadian Rhythm Feedback Hydrogen-Ion Concentration Membrane Potentials Membranes/physiology Models, Biological Periodicity Protons
Chemicals
Carrier Proteins Protons
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Chay T R
References (12)
12 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.4.2204
Published
1981-04-00
Pages
2204-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC319312
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.78.4.2204 PMC Full Text View journal details
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