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PMID: 6264111 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Isolation of a protein kinase induced by herpes simplex virus type 1.

Journal of virology ·Vol. 38 ·No. 1 ·1981-04-00 ·Pages 383-8

Blue WT, Stobbs DG

Abstract

We have isolated a new cyclic AMP-independent protein kinase activity induced in HeLa cells by infection with herpes simplex virus type 1. Induction of the enzyme does not occur in cells treated with cycloheximide at the time of infection, or in cells infected with UV-inactivated herpes simplex virus type 1. The amount of enzyme induced in infected cells is dependent upon the multiplicity of infection. An enzyme with identical properties to the appearing in infected HeLa cells is also induced by herpes simplex virus type 1 in BHK cells.

MeSH Terms
Cycloheximide/pharmacology Enzyme Induction/drug effects,radiation effects Protein Kinases/biosynthesis,isolation & purification Simplexvirus/enzymology Ultraviolet Rays
Chemicals
Cycloheximide Protein Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Blue W T
Stobbs D G
References (31)
31 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.38.1.383-388.1981
Published
1981-04-00
Pages
383-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC171163
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.38.1.383-388.1981 PMC Full Text View journal details
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