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PMID: 6251257 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Induction of neoplasms by subgroup E recombinants of exogenous and endogenous avian retroviruses (Rous-associated virus type 60).

Journal of virology ·Vol. 33 ·No. 2 ·1980-02-00 ·Pages 915-9

Crittenden LB, Hayward WS, Hanafusa H, Fadly AM

Abstract

Chickens susceptible to infection with subgroup E viruses were inoculated with four independent isolates of Rous-associated virus type 60 (RAV-60) that are subgroup e recombinants of endogenous and exogenous virus. Neoplasms developed in each inoculated group. Therefore, nontransforming viruses of subgroup E can induce lymphoid leukosis at a moderate rate compared with RAV-0, a subgroup E endogenous virus, suggesting that oncogenicity is not a viral envelope (env)-related characteristic. Since the common (c) regions of the RAV-60s examined were of exogenous origin, we suggest that the c region rather than env is important for a high rate of induction of lymphoid leukosis and related neoplasms.

MeSH Terms
Animals Avian Leukosis/etiology Avian Leukosis Virus/genetics,pathogenicity Avian Sarcoma Viruses/genetics,pathogenicity Chick Embryo Chickens Neoplasms, Experimental/etiology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Crittenden L B
Hayward W S
Hanafusa H
Fadly A M
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25 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.33.2.915-919.1980
Published
1980-02-00
Pages
915-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC288618
Subset
IM
Grants
NCI NIH HHS · CA 14935 · United States
NCI NIH HHS · CA 18213 · United States
NCI NIH HHS · YO1-CP-4-0214 · United States
External Links
PubMed source DOI: 10.1128/JVI.33.2.915-919.1980 PMC Full Text View journal details
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