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PMID: 6251113 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Parathyroid hormone acutely increases polyphosphoinositides of the rabbit kidney cortex by a cycloheximide-sensitive process.

The Journal of clinical investigation ·Vol. 65 ·No. 6 ·1980-06-00 ·Pages 1523-6

Farese RV, Bidot-López P, Sabir A, Smith JS, Schinbeckler B, Larson R

Abstract

Parathyroid hormone(PTH) rapidly increases the concentrations of diphosphoinositide and triphosphoinositide in rabbit kidney cortex. Cycloheximide pretreatment abolishes these effects of PTH. These findings are similar to those reported for adrenocorticotropin and cyclic AMP action in the adrenal cortex, and suggest a common mechanism. Cycloheximide-sensitive effects of PTH, e.g., phosphaturia, may require polyphosphoinositides and/or other phospholipids.

MeSH Terms
Animals Cycloheximide/pharmacology Kidney Cortex/metabolism Male Parathyroid Hormone/antagonists & inhibitors,pharmacology Phosphatidylinositols/metabolism Rabbits Stimulation, Chemical
Chemicals
Parathyroid Hormone Phosphatidylinositols Cycloheximide
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Farese R V
Bidot-López P
Sabir A
Smith J S
Schinbeckler B
Larson R
References (21)
21 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI109818
Published
1980-06-00
Pages
1523-6
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC371492
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI109818 PMC Full Text View journal details
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