Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol.

The Journal of clinical investigation ·Vol. 51 ·No. 9 ·1972-09-00 ·Pages 2502-4

Rasmussen H, Wong M, Bikle D, Goodman DB

Abstract

Isolated renal tubules from vitamin D-deficient chicks catalyse the in vitro conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol. This conversion is stimulated by 5 x 10(-10) M bovine parathyroid hormone, or by 10(-6) M cyclic AMP. It is inhibited by 10(-9) M porcine calcitonin. It is concluded that these hormonal controls of the synthesis of the renal hormone 1,25-dihydroxycholecalciferol are of particular physiological significance in coordinating the activities of the various organs involved in extracellular calcium homeostasis.

MeSH Terms

Animals Calcitonin/pharmacology Calcium/metabolism Chickens Culture Techniques Cyclic AMP/pharmacology Hydroxycholecalciferols/analysis,metabolism Kidney Tubules/metabolism Methods Parathyroid Hormone/pharmacology Stimulation, Chemical Vitamin D Deficiency/metabolism

Chemicals

Hydroxycholecalciferols Parathyroid Hormone Calcitonin Cyclic AMP Calcium

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Rasmussen H

Wong M

Bikle D

Goodman D B

References (12)

12 references, click to expand

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Parathyroid hormone, 3'5' AMP, Ca++, and renal gluconeogenesis.
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Unique biosynthesis by kidney of a biological active vitamin D metabolite.
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A rapidly acting metabolite of vitamin D3.
Proc Natl Acad Sci U S A. 1971 Jan;68(1):177-81 PMID: 4322260
Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine.
Biochemistry. 1971 Jul 6;10(14):2799-804 PMID: 4326883
Regulation by calcium of in vivo synthesis of 1,25-dihydroxycholecalciferol and 21,25-dihydroxycholecalciferol.
Proc Natl Acad Sci U S A. 1971 Sep;68(9):2131-4 PMID: 4332247
1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture.
Science. 1972 Feb 18;175(4023):768-9 PMID: 4333399
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Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI107065

Published

1972-09-00

Pages

2502-4

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC292420

Subset

External Links

PubMed source DOI: 10.1172/JCI107065 PMC Full Text View journal details

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Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol.

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