Home LiteratureArticle Details
PMID: 6249881 Published · ppublish English Journal Article

Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains.

The Journal of experimental medicine ·Vol. 152 ·No. 1 ·1980-07-01 ·Pages 219-28

Kozak CA, Rowe WP

Abstract

A single mendelian gene was identified for induction of the endogenous xenotropic murine leukemia virus in five mouse strains (C57BL/10, C57L, C57BR, AKR, and BALB/c). This locus, designated Bxv-1, mapped to the same site on chromosome 1 in all strains: Id-1-Pep-3-[Bxv-1-Lp]. Thus, inducibility loci for xenotropic virus are more limited in number and chromosomal distribution than ecotropic inducibility loci. Virus expression in mice with Bxv-1 was induced by treatment of fibroblasts with 5-iododeoxyuridine or by exposure of spleen cells to a B cell mitogen, bacterial lipopolysaccharide. An analysis of the hamster X mouse somatic cell hybrids indicated that chromosome 1, alone, was sufficient for virus induction.

MeSH Terms
Alleles Animals Chromosome Mapping Cricetinae Genes, Viral Genetic Markers Hybrid Cells/cytology Idoxuridine/pharmacology Karyotyping Leukemia Virus, Murine/genetics Mice Mice, Inbred Strains Recombination, Genetic Virus Activation
Chemicals
Genetic Markers Idoxuridine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kozak C A
Rowe W P
References (20)
20 references, click to expand
  1. Genetically determined variation of adenylate kinase in man.
    Nature. 1966 Jan 15;209(5020):261-3 PMID: 5915956
  2. Demonstration of biological activity of a murine leukemia virus of New Zealand black mice.
    Science. 1970 Oct 16;170(3955):326-7 PMID: 4318971
  3. Studies of genetic transmission of murine leukemia virus by AKR mice. I. Crosses with Fv-1 n strains of mice.
    J Exp Med. 1972 Nov 1;136(5):1272-85 PMID: 4343244
  4. Genetic mapping of a murine leukemia virus-inducing locus of AKR mice.
    Science. 1972 Nov 24;178(4063):860-2 PMID: 4343696
  5. A system of nomenclature for band patterns of mouse chromosomes.
    Chromosoma. 1973;41(2):145-58 PMID: 4120886
  6. Segregation of loci for C-type virus induction in strains of mice with high and low incidence of leukemia.
    Science. 1973 May 25;180(4088):865-6 PMID: 4122421
  7. A type-C virus in human rhabdomyosarcoma cells after inoculation into NIH Swiss mice treated with antithymocyte serum.
    Proc Natl Acad Sci U S A. 1973 Mar;70(3):859-62 PMID: 4123693
  8. Independent segregation of loci for activation of biologically distinguishable RNA C-type viruses in mouse cells.
    Proc Natl Acad Sci U S A. 1973 Jul;70(7):2055-8 PMID: 4352968
  9. Genetic factors in the natural history of murine leukemia virus infection: G. H. A. Clowes Memorial Lecture.
    Cancer Res. 1973 Dec;33(12):3061-8 PMID: 4357347
  10. A review of enzyme polymorphism, linkage and electrophoretic conditions for mouse and somatic cell hybrids in starch gels.
    J Histochem Cytochem. 1973 Dec;21(12):1066-81 PMID: 4587225
  11. An in vitro focus-induction assay for xenotropic murine leukemia virus, feline leukemia virus C, and the feline--primate viruses RD-114/CCC/M-7.
    Virology. 1975 Sep;67(1):288-91 PMID: 170737
  12. Polymorphism and linkage of glutathione reductase in Mus musculus.
    Biochem Genet. 1975 Jun;13(5-6):323-9 PMID: 1180875
  13. A sequential staining technique for the chromosomal analysis of the interspecific mouse/hamster and mouse/human somatic cell hybrids.
    Exp Cell Res. 1977 Mar 1;105(1):109-17 PMID: 65290
  14. Human red cell glyoxalase I polymorphism.
    Biochem Genet. 1977 Feb;15(1-2):109-13 PMID: 66916
  15. Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome.
    Somatic Cell Genet. 1975 Oct;1(4):371-82 PMID: 1235912
  16. Mendelian segregation of loci controlling xenotropic virus production in NZB crosses.
    Virology. 1977 Dec;83(2):449-52 PMID: 929987
  17. A procedure for culture of cells from mouse tail biopsies: brief communication.
    J Natl Cancer Inst. 1978 Feb;60(2):477-8 PMID: 621760
  18. Genetic mapping of xenotropic leukemia virus-inducing loci in two mouse strains.
    Science. 1978 Mar 31;199(4336):1448-9 PMID: 204014
  19. Leukemia virus genomes in the chromosomal DNA of the mouse.
    Harvey Lect. 1978;71:173-92 PMID: 213400
  20. Differential expression of two distinct xenotropic viruses in NZB mice.
    Clin Immunol Immunopathol. 1980 Mar;15(3):493-501 PMID: 7371228
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.152.1.219
Published
1980-07-01
Pages
219-28
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2185909
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.152.1.219 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2