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PMID: 6246891 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Capillaries of the adrenal cortex possess aminopeptidase A and angiotensin-converting-enzyme activities.

The Biochemical journal ·Vol. 186 ·No. 2 ·1980-02-15 ·Pages 605-8

Del Vecchio PJ, Ryan JW, Chung A, Ryan US

Abstract

The enzymes required to convert the prohormone angiotensin I into angiotensins II and III, secretagogues of aldosterone, are enriched in association with capillary endothelium isolated from rat adrenal cortex. Thus the secretion of aldosterone may be controlled, in part, by processing of peptides occurring within the adrenal gland itself.

MeSH Terms

Adrenal Cortex/blood supply,enzymology,ultrastructure Aminopeptidases/metabolism Animals Capillaries/enzymology,ultrastructure Endothelium/enzymology Female Microscopy, Electron Peptidyl-Dipeptidase A/metabolism Rats

Chemicals

Aminopeptidases Peptidyl-Dipeptidase A

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Del Vecchio P J

Ryan J W

Chung A

Ryan U S

References (16)

16 references, click to expand

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Eur J Pharmacol. 1976 Jul;38(1):113-21 PMID: 954820
[Des-Asp1] angiotensin II: mediator of the renin-angiotensin system?
Fed Proc. 1977 Apr;36(5):1766-70 PMID: 321257
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Circ Res. 1977 Aug;41(2):231-8 PMID: 194729
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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1860605

Published

1980-02-15

Pages

605-8

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1161614

Subset

External Links

PubMed source DOI: 10.1042/bj1860605 PMC Full Text View journal details

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Capillaries of the adrenal cortex possess aminopeptidase A and angiotensin-converting-enzyme activities.

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