Home LiteratureArticle Details
PMID: 6246273 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

BK virus DNA sequence coding for the t and T antigens and evaluation of methods for determining sequence homology.

Journal of virology ·Vol. 34 ·No. 2 ·1980-05-00 ·Pages 416-30

Yang RC, Young A, Wu R

Abstract

The DNA sequence of the early region of the human papovavirus BK (MM strain) was determined. A potential initiation signal for translation is located at nucleotides 3,047 to 3,045 or map position 0.614. Extending counterclockwise from this AUG signal there is only one open reading frame, which can code for a putative t antigen of 100 amino acids in length. If the early mRNA of BKV is spliced, then the regions between nucleotides 3,047 to 2,808 and 2,725 to 884 can code for a T antigen 694 amino acids in length. The sequences of the deduced T antigens in BK virus share 71% amino acid homology with those in simian virus 40, whereas the coding sequences of the two viruses share 70% DNA homology. Comparison of DNA sequences and evaluation of homology measurements between these two viruses are discussed.

MeSH Terms
Antigens, Neoplasm/analysis,genetics Antigens, Viral/analysis,genetics BK Virus/genetics,immunology Base Sequence Codon DNA, Viral/genetics Genetic Code Nucleic Acid Hybridization Polyomavirus/genetics Simian virus 40/analysis
Chemicals
Antigens, Neoplasm Antigens, Viral Codon DNA, Viral
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yang R C
Young A
Wu R
References (51)
51 references, click to expand
  1. Thermodynamic and kinetic studies on the interconversion between the linear and circular forms of phage lambda DNA.
    J Mol Biol. 1966 Jan;15(1):111-23 PMID: 5912035
  2. Selective extraction of polyoma DNA from infected mouse cell cultures.
    J Mol Biol. 1967 Jun 14;26(2):365-9 PMID: 4291934
  3. Cyclization of coliphage 186 DNA.
    J Mol Biol. 1967 Sep 28;28(3):403-11 PMID: 6052645
  4. Nucleotide sequence analysis of DNA. II. Complete nucleotide sequence of the cohesive ends of bacteriophage lambda DNA.
    J Mol Biol. 1971 May 14;57(3):491-511 PMID: 4931680
  5. New human papovavirus (B.K.) isolated from urine after renal transplantation.
    Lancet. 1971 Jun 19;1(7712):1253-7 PMID: 4104714
  6. Nucleotide sequence analysis of DNA. IV. Complete nucleotide sequence of the left-hand cohesive end of coliphage 186 DNA.
    J Mol Biol. 1972 Apr 14;65(3):447-67 PMID: 4554112
  7. Human papovavirus, BK strain: biological studies including antigenic relationship to simian virus 40.
    J Virol. 1973 Sep;12(3):625-31 PMID: 4355860
  8. Improved estimation of secondary structure in ribonucleic acids.
    Nat New Biol. 1973 Nov 14;246(150):40-1 PMID: 4519026
  9. Malignant transformation of BHK21 clone 13 cells by BK virus--a human papovavirus.
    Proc Natl Acad Sci U S A. 1973 Nov;70(11):3210-2 PMID: 4361683
  10. Isolation of papovavirus from brain tumor and urine of a patient with Wiskott-Aldrich syndrome.
    J Natl Cancer Inst. 1974 Nov;53(5):1205-7 PMID: 4214938
  11. Malignant transformation of hamster kidney cells by BK virus.
    J Virol. 1975 Feb;15(2):420-2 PMID: 163364
  12. Sarcoma in a hamster inoculated with BK virus, a human papovavirus.
    J Natl Cancer Inst. 1975 Apr;54(4):945-50 PMID: 165302
  13. Physical map of the BK virus genome.
    J Virol. 1975 Oct;16(4):959-73 PMID: 170425
  14. Homology and relationship between the genomes of papovaviruses, BK virus and simian virus 40.
    Proc Natl Acad Sci U S A. 1975 Jul;72(7):2563-7 PMID: 170606
  15. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
  16. Infectivity, oncogenicity and transforming ability of BK virus and BK virus DNA.
    J Gen Virol. 1976 Mar;30(3):371-3 PMID: 176315
  17. Complementation between BK human papovavirus and a simian virus 40 tsA mutant.
    J Virol. 1976 Mar;17(3):1060-2 PMID: 176441
  18. Comparison of JC and BK human papovaviruses with simian virus 40: DNA homology studies.
    J Virol. 1976 Aug;19(2):675-84 PMID: 183019
  19. Cell-free translation of simian virus 40 early messenger RNA coding for viral T-antigen.
    Proc Natl Acad Sci U S A. 1977 Feb;74(2):457-61 PMID: 191809
  20. A new method for sequencing DNA.
    Proc Natl Acad Sci U S A. 1977 Feb;74(2):560-4 PMID: 265521
  21. The genome of simian virus 40.
    Adv Virus Res. 1977;21:85-173 PMID: 193382
  22. Synthesis and thermal melting behavior of oligomer-polymer complexes containing defined lengths of mismatched dA-dG and dG-dG nucleotides.
    Biochemistry. 1977 May 31;16(11):2367-74 PMID: 301042
  23. Molecular biology of papovaviruses.
    Annu Rev Biochem. 1977;46:471-522 PMID: 197880
  24. Physical and genetic characterization of deletion mutants of simian virus 40 constructed in vitro.
    J Virol. 1977 Oct;24(1):277-94 PMID: 198579
  25. Relationship between the methionine tryptic peptides of simian virus 40 and BK virus tumor antigens.
    J Virol. 1977 Oct;24(1):319-25 PMID: 198582
  26. Novel mechanism for RNA maturation: the leader sequences of simian virus 40 mRNA are not transcribed adjacent to the coding sequences.
    Proc Natl Acad Sci U S A. 1977 Sep;74(9):3686-90 PMID: 198797
  27. Electron microscope study of the base sequence homology between simian virus 40 and human papovavirus BK.
    J Virol. 1978 Jan;25(1):193-201 PMID: 202735
  28. Nucleotide sequence of the DNA replication origin for human papovavirus BKV: sequence and structural homology with SV40.
    Cell. 1978 Feb;13(2):345-58 PMID: 203403
  29. Organization and expression of early genes of simian virus 40.
    Proc Natl Acad Sci U S A. 1978 Jan;75(1):117-21 PMID: 203926
  30. Analysis of human tumors and human malignant cell lines for BK virus-specific DNA sequences.
    Proc Natl Acad Sci U S A. 1978 Jan;75(1):454-8 PMID: 203940
  31. The use of thin acrylamide gels for DNA sequencing.
    FEBS Lett. 1978 Mar 1;87(1):107-10 PMID: 631324
  32. Complete nucleotide sequence of SV40 DNA.
    Nature. 1978 May 11;273(5658):113-20 PMID: 205802
  33. The genome of simian virus 40.
    Science. 1978 May 5;200(4341):494-502 PMID: 205947
  34. Common methionine-tryptic peptides near the amino-terminal end of primate papovavirus tumor antigens.
    Proc Natl Acad Sci U S A. 1978 Mar;75(3):1131-5 PMID: 206886
  35. Spliced early mRNAs of simian virus 40.
    Proc Natl Acad Sci U S A. 1978 Mar;75(3):1274-8 PMID: 206891
  36. BK virus DNA: cleavage map and sequence analysis.
    Proc Natl Acad Sci U S A. 1978 May;75(5):2150-4 PMID: 209454
  37. Large and small tumor antigens from simian virus 40 have identical amino termini mapping at 0.65 map units.
    Proc Natl Acad Sci U S A. 1978 May;75(5):2165-9 PMID: 209456
  38. Somatic cell hybrids producing antibodies specific for the tumor antigen of simian virus 40.
    Proc Natl Acad Sci U S A. 1978 May;75(5):2320-3 PMID: 79181
  39. Cleavage map of BK virus DNA with restriction endonucleases MboI and HaeIII.
    J Virol. 1978 Sep;27(3):700-12 PMID: 212590
  40. Viral, prokaryote and eukaryote genes contrasted by mRNA sequence indexes.
    FEBS Lett. 1978 Nov 1;95(1):1-11 PMID: 214340
  41. Physical mapping of BK virus DNA with SacI, MboII, and AluI restriction endonucleases.
    J Virol. 1978 Dec;28(3):851-64 PMID: 215783
  42. Heterogeneity and 5'-terminal structures of the late RNAs of simian virus 40.
    J Mol Biol. 1978 Dec 25;126(4):813-46 PMID: 218021
  43. Nucleotide sequence of the BK virus DNA segment encoding small t antigen.
    Proc Natl Acad Sci U S A. 1979 Feb;76(2):565-9 PMID: 218208
  44. BK virus DNA sequence coding for the amino-terminus of the T-antigen.
    Virology. 1979 Jan 30;92(2):340-52 PMID: 218348
  45. Transformation of human embryonic kidney cells by human papovarirus BK.
    J Virol. 1979 Feb;29(2):763-9 PMID: 219257
  46. A rapid method for detecting and mapping homology between heterologous DNAs. Evaluation of polyomavirus genomes.
    J Biol Chem. 1979 Jun 10;254(11):4876-83 PMID: 220264
  47. BK virus DNA sequence: extent of homology with simian virus 40 DNA.
    Proc Natl Acad Sci U S A. 1979 Mar;76(3):1179-83 PMID: 220609
  48. Mapping and ordering of fragments of BK virus DNA produced by restriction endonucleases.
    J Virol. 1979 Mar;29(3):915-25 PMID: 221680
  49. Comparative study of papovavirus DNA: BKV(MM), BKV(WT) and SV40.
    Nucleic Acids Res. 1979 Oct 10;7(3):651-68 PMID: 228246
  50. BK virus DNA: complete nucleotide sequence of a human tumor virus.
    Science. 1979 Oct 26;206(4417):456-62 PMID: 228391
  51. The genome of human papovavirus BKV.
    Cell. 1979 Dec;18(4):963-77 PMID: 229976
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.34.2.416-430.1980
Published
1980-05-00
Pages
416-30
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC288720
Subset
IM
Databases
GENBANK
J02039, J02040, K01471
External Links
PubMed source DOI: 10.1128/JVI.34.2.416-430.1980 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2