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PMID: 6216933 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Differentiation of the mammary gland and susceptibility to carcinogenesis.

Breast cancer research and treatment ·Vol. 2 ·No. 1 ·1982-00-00 ·Pages 5-73

Russo J, Tay LK, Russo IH

Abstract

It has been demonstrated that in humans certain factors such as early menarche, late pregnancy, and nulliparity are associated with a higher risk of developing breast cancer, while early pregnancy acts as a protective factor. Induction of mammary cancer in rats by administration of the chemical carcinogen 7,12-dimethylbenz(a)anthracene reveals that the same factors influencing human breast cancer risk also affect the susceptibility of the rat mammary gland to the chemical carcinogen. Nulliparous rats and rats undergoing pregnancy interruption are more susceptible to developing carcinomas. This fact has been attributed to the incomplete differentiation of the gland at the time of carcinogen administration. Parous rats are resistant to the carcinogenic effect of DMBA, which is explained by the complete development of the gland attained during pregnancy and lactation. This development is manifested by the differentiation of terminal end buds into secretory units, which have a smaller proliferative compartment; the epithelial cells of these secretory units have a longer cell cycle, less avidity for binding DMBA, and possess a more efficient DNA excision repair capacity.

MeSH Terms
9,10-Dimethyl-1,2-benzanthracene/metabolism,pharmacology Abortion, Induced Adenosine Triphosphatases/analysis Aging Animals Antigens Breast Neoplasms/etiology Cell Cycle DNA/biosynthesis DNA Repair Disease Susceptibility Epithelial Cells Female Humans Mammary Glands, Animal/cytology,growth & development,immunology Mammary Neoplasms, Experimental/chemically induced,etiology Maternal Age Parity Pregnancy Rats Rats, Inbred Strains
Chemicals
Antigens 9,10-Dimethyl-1,2-benzanthracene DNA Adenosine Triphosphatases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Russo J
Tay L K
Russo I H
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Article Info
Journal
Breast cancer research and treatment
Abbr.
Breast Cancer Res Treat
ISSN
0167-6806
DOI
10.1007/BF01805718
Published
1982-00-00
Pages
5-73
Language
English
Region
Netherlands
NLM ID
8111104
Subset
IM
Grants
NCI NIH HHS · CA 23539 · United States
NCI NIH HHS · CA 27026 · United States
External Links
PubMed source DOI: 10.1007/BF01805718 View journal details
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