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PMID: 265591 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Excision repair of benzo[a]pyrene-deoxyguanosine adducts in baby hamster kidney 21/C13 cells and in secondary mouse embryo fibroblasts C57BL/6J.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 3 ·1977-03-00 ·Pages 979-83

Shinohara K, Cerutti PA

Abstract

The formation and excision of benzo[a]pyrene-deoxyguanosine adducts in metabolizing baby hamster kidney cells (21/C13) and secondary mouse embryo fibroblasts (C57BL/6J) was investigated. Both diastereomeric adducts, N2-(10-(7beta,8alpha,9alpha-trihydroxy-7, 8, 9, 10 tetrahydrobenzo[a]-7,8,9,10-tetrahydrobenzo[a]pyrene)yl)deoxyguanosine, were detected in both cell lines and both cell lines were capable of excising these lesions, albeit with low efficiency.

MeSH Terms
Benzopyrenes/metabolism Cell Line DNA Repair Deoxyribonucleosides Guanosine/analogs & derivatives,metabolism Kinetics
Chemicals
Benzopyrenes Deoxyribonucleosides Guanosine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Shinohara K
Cerutti P A
References (28)
28 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.74.3.979
Published
1977-03-00
Pages
979-83
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC430554
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.74.3.979 PMC Full Text View journal details
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