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PMID: 6203738 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus.

The EMBO journal ·Vol. 1 ·No. 7 ·1982-00-00 ·Pages 869-74

Pfaff E, Mussgay M, Böhm HO, Schulz GE, Schaller H

Abstract

A major antibody combining site on foot and mouth disease virus (FMDV) serotype O1K has been identified in a predicted surface helix of viral protein 1 (VP1) between amino acid residues 144 and 159. A hexadecapeptide covering this sequence elicits high titers of antibodies that specifically recognize and neutralize FMDV. The high quality of the immune response is attributed to a particularly stable conformation of the antigenic amino acid sequence, which is most likely an alpha-helix.

MeSH Terms

Amino Acid Sequence Animals Antibodies, Viral Antigen-Antibody Complex Antigens, Viral/genetics Aphthovirus/genetics,immunology Enzyme-Linked Immunosorbent Assay Epitopes/analysis Genes, Viral Serotyping

Chemicals

Antibodies, Viral Antigen-Antibody Complex Antigens, Viral Epitopes

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Pfaff E

Mussgay M

Böhm H O

Schulz G E

Schaller H

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28 references, click to expand

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Article Info

Journal

The EMBO journal

Abbr.

EMBO J

ISSN

0261-4189

Published

1982-00-00

Pages

869-74

Language

English

Region

England

NLM ID

8208664

PMCID

PMC553124

Subset

External Links

PubMed source PMC Full Text View journal details

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Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus.

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