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PMID: 6198422 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cloned LYT-2+ cytolytic T lymphocytes destroy allogeneic tissue in vivo.

The Journal of experimental medicine ·Vol. 159 ·No. 1 ·1984-01-01 ·Pages 234-43

Tyler JD, Galli SJ, Snider ME, Dvorak AM, Steinmuller D

Abstract

The long-accepted notion that alloimmune cytolytic T cells (CTL) mediate transplantation immunity has recently been called into question. In order to ascertain directly whether alloimmune CTL can mediate destruction of foreign tissue, we tested the ability of mouse CTL expanded as cloned populations in vitro to destroy allogeneic skin in vivo. The results of these studies prove unequivocally that cloned Lyt-2+ CTL can perform this task in an immunologically specific, H-2-restricted, and dose-dependent fashion.

MeSH Terms
Animals Antigens, Ly/genetics,immunology Clone Cells/immunology Dose-Response Relationship, Immunologic Epitopes H-2 Antigens/genetics,immunology Immunization, Passive Mice Mice, Inbred A Mice, Inbred AKR Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred CBA Phenotype Skin Diseases/etiology,immunology,pathology T-Lymphocytes, Cytotoxic/immunology,transplantation,ultrastructure
Chemicals
Antigens, Ly Epitopes H-2 Antigens
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Tyler J D
Galli S J
Snider M E
Dvorak A M
Steinmuller D
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32 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.159.1.234
Published
1984-01-01
Pages
234-43
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187201
Subset
IM
Grants
NIAID NIH HHS · AI 16925 · United States
NIAID NIH HHS · AI 20477 · United States
NCI NIH HHS · CA 01927 · United States
External Links
PubMed source DOI: 10.1084/jem.159.1.234 PMC Full Text View journal details
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