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PMID: 7044959 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Delayed-type hypersensitivity and allograft rejection in the mouse: correlation of effector cell phenotype.

Immunology ·Vol. 46 ·No. 2 ·1982-06-00 ·Pages 313-20

Loveland BE, McKenzie IF

Abstract

Delayed-type hypersensitivity (DTH) responses to alloantigens were found to correlate with both skin and tumour allograft rejection in 224 reconstituted ATXBM-CBA mice. Furthermore, DTH responses and allograft rejection were observed only in mice that had received Ly-1 cells. Depletion of Thy-1+ or Ly-1+ cells led to indefinite graft survival and the absence of DTH responses, whereas depletion of Ly-2+ cells led to rapid graft rejection and strong DTH responses. The same result was obtained with CBA mice responding to grafts of either C57BL/6 skin, the B16 melanoma, or the EL4 lymphoma; and for (CBA X A)F1 mice responding to H-2K region alloantigens of AQR skin grafts. Thus, DTH and allograft rejection are both mediated by a Ly-1 T cell and it is considered that these are two different manifestations of the same transplantation response.

MeSH Terms
Animals Cyclophosphamide/pharmacology Graft Rejection H-2 Antigens/immunology Hypersensitivity, Delayed/immunology Male Mice Mice, Inbred Strains Neoplasm Transplantation Neoplasms, Experimental/immunology Phenotype Skin Transplantation T-Lymphocytes/immunology Time Factors
Chemicals
H-2 Antigens Cyclophosphamide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Loveland B E
McKenzie I F
References (21)
21 references, click to expand
  1. Quantitative studies on tissue transplantation immunity. VII. The normal lymphocyte transfer reaction.
    Proc R Soc Lond B Biol Sci. 1966 Sep 13;165(1000):281-307 PMID: 4380527
  2. Inducer T lymphocytes synthesize a factor that stimulates proliferation of cloned mast cells.
    Nature. 1981 May 28;291(5813):332-4 PMID: 6972009
  3. Interleukin-2 augments natural killer cell activity.
    Nature. 1981 May 28;291(5813):335-8 PMID: 6164929
  4. An analysis of the genetic requirements for delayed cutaneous hypersensitivity reactions to transplantation antigens in mice.
    J Exp Med. 1970 Feb;131(2):409-27 PMID: 4392949
  5. Monoclonal antibodies to murine cell surface antigens. I. Lyt-1.1.
    J Immunol. 1980 Oct;125(4):1618-24 PMID: 6997382
  6. Delayed type hypersensitivity to allogeneic cells in mice. I. Requirements for optimal sensitization and definition of the response.
    Int Arch Allergy Appl Immunol. 1979;58(3):285-94 PMID: 84800
  7. Effector mechanisms in allograft rejection. II. Density, electrophoresis, and size fractionation of allograft-infiltrating cells demonstrating several classes of killer cells.
    Cell Immunol. 1977 May;30(2):236-53 PMID: 301064
  8. Effector mechanisms in allograft rejection. IV. In contrast to late cytotoxic cells, and early killer cells infiltrating mouse sponge matrix allografts are predominantly T lymphocytes.
    Cell Immunol. 1978 Jul;38(2):255-63 PMID: 307985
  9. Skin transplantation immunity in relation to hypersensitivity.
    Lancet. 1958 Sep 13;2(7046):561-4 PMID: 13576872
  10. HOMOGRAFT SENSITIVITY REACTIONS IN IRRADIATED HAMSTERS.
    Lancet. 1965 Mar 20;1(7386):622-4 PMID: 14255213
  11. Effects of costimulator on immune responses in vitro.
    J Immunol. 1978 Jun;120(6):1974-80 PMID: 149174
  12. Cell-mediated hyperacute rejection. I. Acute, accelerated, and hyperacute reactions.
    Transplantation. 1981 Mar;31(3):156-9 PMID: 7015608
  13. Delayed hypersensitivity in the mouse.
    Adv Immunol. 1975;20:197-264 PMID: 47220
  14. Evaluation in primate renal allograft recipients of monoclonal antibody to human T-cell subclasses.
    Transplant Proc. 1981 Mar;13(1 Pt 1):499-503 PMID: 7022882
  15. Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection.
    J Exp Med. 1981 May 1;153(5):1044-57 PMID: 7019377
  16. Allergy in experimental mouse tuberculosis.
    Am Rev Tuberc. 1955 Aug;72(2):171-95 PMID: 13238778
  17. Genetic aspects of second-set skin grafts in mice.
    Transplantation. 1966 May;4(3):260-73 PMID: 5335855
  18. Delayed cutaneous hypersensitivity and human renal allotransplantation.
    Transplant Proc. 1977 Mar;9(1):81-3 PMID: 325815
  19. Partial characterization of cytotoxic cells infiltrating sponge matrix allografts.
    Transplantation. 1979 Apr;27(4):254-9 PMID: 155912
  20. Two subsets of rat T lymphocytes defined with monoclonal antibodies.
    Eur J Immunol. 1980 Aug;10(8):609-15 PMID: 6967416
  21. T-lymphocyte heterogeneity in the rat: separation of functional subpopulations using a monoclonal antibody.
    J Exp Med. 1978 Sep 1;148(3):664-73 PMID: 29936
Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1982-06-00
Pages
313-20
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1555378
Subset
IM
Grants
NCI NIH HHS · CA-22080 · United States
External Links
PubMed source PMC Full Text View journal details
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