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PMID: 6193099 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Spectinomycin resistance due to a mutation in an rRNA operon of Escherichia coli.

Journal of bacteriology ·Vol. 155 ·No. 3 ·1983-09-00 ·Pages 989-94

Mark LG, Sigmund CD, Morgan EA

Abstract

A spectinomycin resistance mutation was isolated in an Escherichia coli rRNA operon (rrnH) located on a multicopy plasmid. Cell-free protein-synthesizing extracts made from cells containing the plasmid were partially resistant to spectinomycin. Although spectinomycin is an aminoglycoside antibiotic, the mutation did not confer resistance to any other aminoglycoside antibiotic tested.

MeSH Terms
Aminoglycosides/pharmacology Anti-Bacterial Agents/pharmacology Bacterial Proteins/biosynthesis Drug Resistance, Microbial Escherichia coli/drug effects,genetics,metabolism Mutation Operon Plasmids RNA, Bacterial/genetics RNA, Ribosomal/genetics Spectinomycin/pharmacology
Chemicals
Aminoglycosides Anti-Bacterial Agents Bacterial Proteins RNA, Bacterial RNA, Ribosomal Spectinomycin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Mark L G
Sigmund C D
Morgan E A
References (31)
31 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.155.3.989-994.1983
Published
1983-09-00
Pages
989-94
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC217790
Subset
IM
Grants
NIGMS NIH HHS · 1RO1GM27664-03 · United States
External Links
PubMed source DOI: 10.1128/jb.155.3.989-994.1983 PMC Full Text View journal details
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