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PMID: 6185427 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Antigenic differences among isolates of Plasmodium falciparum demonstrated by monoclonal antibodies.

Infection and immunity ·Vol. 38 ·No. 3 ·1982-12-00 ·Pages 893-7

Schofield L, Saul A, Myler P, Kidson C

Abstract

Hybridomas raised against two Papua New Guinea (PNG) isolates of Plasmodium falciparum secreted monoclonal antibodies which bound to schizonts of all seven PNG isolates tested but not to schizonts of four non-PNG isolates from Thailand, Nigeria, Ghana, and The Netherlands. Some of the monoclonal antibodies were tested for their ability to inhibit the growth of one PNG isolate, one Thai isolate, and one Nigerian isolate in vitro. Only the growth of the PNG isolate was inhibited, thus demonstrating functional antigenic differences among isolates of P. falciparum.

MeSH Terms

Animals Antibodies, Monoclonal/immunology Antigens/immunology Epitopes Papua New Guinea Plasmodium falciparum/immunology,isolation & purification

Chemicals

Antibodies, Monoclonal Antigens Epitopes

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Schofield L

Saul A

Myler P

Kidson C

References (14)

14 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.38.3.893-897.1982

Published

1982-12-00

Pages

893-7

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC347833

Subset

External Links

PubMed source DOI: 10.1128/iai.38.3.893-897.1982 PMC Full Text View journal details

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Antigenic differences among isolates of Plasmodium falciparum demonstrated by monoclonal antibodies.

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