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PMID: 6164634 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Hybrid (combinatorial) Ia specificities: gene complementations to generate Ia.22.

Immunogenetics ·Vol. 13 ·No. 1-2 ·1981-00-00 ·Pages 115-25

Lafuse WP, McCormick JF, Corser PS, David CS

Abstract

Ia specificity 22 is expressed on a hybrid I-E molecule formed by the association of a beta chain (Ae) coded for by the I-A subregion and an alpha chain (E alpha) encoded by the I-E subregion. Ia.22 can be generated by the complementation of Ab, Ak, As, Ar, with Ed, Ek, Ep, Er, Ew3, Eu, Ev but Eb, Ef, Eq, and Es. With the exception of H-2p which does not complement with As to generate Ia.22, all Ia. 7-positive (I-E) haplotypes can provide the permissive E alpha allele. It is postulated that Ia.22 is a combinatorial Ia determinant generated by the association of the alpha and beta chains. These determinants are probably involved in the immune recognition of antigens under dual Ir-gene control.

MeSH Terms
Animals Chemical Precipitation Cytotoxicity, Immunologic Epitopes Genetic Complementation Test Histocompatibility Antigens Class II/genetics Hybridization, Genetic Mice Mice, Inbred A Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred DBA
Chemicals
Epitopes Histocompatibility Antigens Class II
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lafuse W P
McCormick J F
Corser P S
David C S
References (23)
23 references, click to expand
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF00524609
Published
1981-00-00
Pages
115-25
Language
English
Region
United States
NLM ID
0420404
Subset
IM
Grants
NIAID NIH HHS · AI-14764 · United States
NCI NIH HHS · CA-24473 · United States
External Links
PubMed source DOI: 10.1007/BF00524609 View journal details
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