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PMID: 6157834 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Association of endogenous retroviruses with radiation-induced leukemias of BALB/c mice.

Journal of virology ·Vol. 33 ·No. 2 ·1980-02-00 ·Pages 652-60

Ellis RW, Stockert E, Fleissner E

Abstract

X-irradiation of BALB/c mice in the second month of life induced a high incidence of generalized lymphatic leukemia of T-cell origin, beginning at 7 months of age. Infectious ecotropic murine leukemia virus (B-tropic predominant over N-tropic) was isolable from all tumor extracts but exhibited a wide titer range among individual leukemias. Detection of infectious xenotropic virus usually required extensive amplification on indicator cells. Dual-tropic (mink cell focus-forming) virus has not been found in the leukemias. Expression of ecotropic virus in tail extracts prepared at 6.5 months of age, although greatly enhanced compared with unirradiated controls, was not found to be prognostic of tumor development in individual mice. We conclude that leukemogenesis does not show a simple dependence on infectious murine leukemia virus expression in these mice.

MeSH Terms
Animals Antigens, Neoplasm/biosynthesis Female Leukemia Virus, Murine/isolation & purification Leukemia, Experimental/etiology,immunology,microbiology Leukemia, Lymphoid/etiology Leukemia, Radiation-Induced/etiology Male Mice Mice, Inbred BALB C/microbiology RNA-Directed DNA Polymerase/biosynthesis
Chemicals
Antigens, Neoplasm RNA-Directed DNA Polymerase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ellis R W
Stockert E
Fleissner E
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41 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.33.2.652-660.1980
Published
1980-02-00
Pages
652-60
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC288589
Subset
IM
Grants
NCI NIH HHS · CA-08748 · United States
NCI NIH HHS · CA-16599 · United States
External Links
PubMed source DOI: 10.1128/JVI.33.2.652-660.1980 PMC Full Text View journal details
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