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PMID: 6097547 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Bee venom inhibits superoxide production by human neutrophils.

Inflammation ·Vol. 8 ·No. 4 ·1984-12-00 ·Pages 385-91

Somerfield SD, Stach JL, Mraz C, Gervais F, Skamene E

Abstract

Investigation of the antiinflammatory properties of bee venom demonstrates that it inhibits production of superoxide anion by human neutrophils in a potent, selective, nontoxic, dose-dependent fashion, both pre- and poststimulation by particulate and soluble activators of the neutrophil oxidative metabolism burst. The effect is not due to receptor competition, superoxide dismutase, and/or catalase activity, scavenging, or indicator media effects. These findings may explain the antiinflammatory effects of whole bee venom in experimental systems, its widespread use in folk medicine, and lead to the development of potent, new antiinflammatory substances for therapeutic use in man.

MeSH Terms
Bee Venoms/pharmacology Dose-Response Relationship, Drug Humans Hydrogen Peroxide/blood In Vitro Techniques N-Formylmethionine Leucyl-Phenylalanine/pharmacology Neutrophils/drug effects,metabolism Superoxides/blood Tetradecanoylphorbol Acetate/pharmacology Zymosan/pharmacology
Chemicals
Bee Venoms Superoxides N-Formylmethionine Leucyl-Phenylalanine Zymosan Hydrogen Peroxide Tetradecanoylphorbol Acetate
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Somerfield S D
Stach J L
Mraz C
Gervais F
Skamene E
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24 references, click to expand
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Article Info
Journal
Inflammation
Abbr.
Inflammation
ISSN
0360-3997
DOI
10.1007/BF00918214
Published
1984-12-00
Pages
385-91
Language
English
Region
United States
NLM ID
7600105
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00918214 View journal details
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