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PMID: 474306 Published · ppublish English Journal Article

Anti-arthritic effect of bee venom.

Agents and actions ·Vol. 9 ·No. 2 ·1979-06-00 ·Pages 205-11

Chang YH, Bliven ML

Abstract

Bee venom, administered subcutaneously, suppressed the development of carrageenan-induced paw edema and adjuvant arthritis in the rat in a dose-related manner. A single dose of bee venom administered subcutaneously the day before or on the day of injection of complete Freund's adjuvant (CFA) effectively suppressed the development of polyarthritis. This suppressive effect decreased progressively as dosing was delayed. Bee venom was found to be most effective when mixed and injected (sub-plantar) together with CFA, the disease-inducing agent. Similarly, antigens such as egg albumin, when incorporated into CFA, and injected into the hind paw, prevented the development of arthritis. These results suggest that at least two mechanisms are involved in the anti-arthritic action of bee venom: (1) alteration of the immune response, probably via antigen competition, and (2) an anti-inflammatory action via corticosteroids or through an as yet undetermined mechanism.

MeSH Terms
Animals Anti-Inflammatory Agents Arthritis/drug therapy Arthritis, Experimental/physiopathology Bee Venoms/administration & dosage,pharmacology Carrageenan Cyclophosphamide/pharmacology Edema/chemically induced,physiopathology Hydrocortisone/pharmacology Male Ovalbumin/pharmacology Rats
Chemicals
Anti-Inflammatory Agents Bee Venoms Cyclophosphamide Carrageenan Ovalbumin Hydrocortisone
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chang Y H
Bliven M L
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24 references, click to expand
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Article Info
Journal
Agents and actions
Abbr.
Agents Actions
ISSN
0065-4299
DOI
10.1007/BF02024736
Published
1979-06-00
Pages
205-11
Language
English
Region
Switzerland
NLM ID
0213341
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02024736
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