Q-banding of human chromosomes after BUdR and BCdR treatment.

Human genetics ·Vol. 31 ·No. 3 ·1976-03-12 ·Pages 309-16

Bühler EM, Tsuchimoto T, Kosztolànyi G, Pia Jurik L

Abstract

Two different Q patterns were found in BUdR and BCdR treated chromosomes of human lymphocyte cultures: X-type pattern, in which Giemsa and quinacrine banding both are reversed; Y-type pattern, in which Q-banding remains conventional in spite of reverse G-banding. Possible mechanisms of these findings are discussed.

MeSH Terms

Azure Stains Base Sequence Bromodeoxycytidine Bromodeoxyuridine Chromosomes/analysis DNA/analysis Deoxycytidine/analogs & derivatives Female Humans Male Quinacrine Mustard Staining and Labeling

Chemicals

Azure Stains Deoxycytidine Bromodeoxycytidine Quinacrine Mustard DNA Bromodeoxyuridine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Bühler E M

Tsuchimoto T

Kosztolànyi G

Pia Jurik L

References (10)

10 references, click to expand

[The mechanism of chromosome segmentation induced by BUDR (5-bromodeoxyuridine)].
Ann Genet. 1974 Sep;17(3):207-11 PMID: 4141588
Microfluorometric analysis of deoxyribonucleic acid replication kinetics and sister chromatid exchanges in human chromosomes.
J Histochem Cytochem. 1974 Jul;22(7):478-91 PMID: 4137061
The fluorescence of quinacrine mustard with nucleic acids.
Nat New Biol. 1973 Oct 24;245(147):240-4 PMID: 4356153
Localization of sister chromatid exchanges in human chromosomes.
Science. 1974 Jul 5;185(4145):74-6 PMID: 4134970
Differential spiralization along mammalian mitotic chromosomes. II. 5-bromodeoxyuridine and 5-bromodeoxycytidine-revealed differentiation in human chromosomes.
Chromosoma. 1974 Jan 29;44(4):343-59 PMID: 4134865
Late replicating bands of human chromosomes demonstrated by fluorochrome and Giemsa staining.
Humangenetik. 1975 Aug 29;29(1):41-59 PMID: 51822
Mechanisms of chromosome banding. V. Quinacrine banding.
Chromosoma. 1975;50(2):111-4 PMID: 48455
Microfluorometric analysis of DNA replication in human X chromosomes.
Exp Cell Res. 1974 Jun;86(2):412-5 PMID: 4842351
[Linear differentiation of the human Y-chromosome].
Tsitologiia. 1975 Jan;17(1):19-23 PMID: 47202
Differential spiralization along mammalian mitotic chromosomes. I. BUdR-revealed differentiation in Chinese hamster chromosomes.
Chromosoma. 1972;38(4):341-65 PMID: 4672290

Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00270860

Published

1976-03-12

Pages

309-16

Language

English

Region

Germany

NLM ID

7613873

PMCID

PMC8332890

Subset

External Links

PubMed source DOI: 10.1007/BF00270860 PMC Full Text View journal details

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Q-banding of human chromosomes after BUdR and BCdR treatment.

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