The effects of acute ethanol feeding and of chronic benfluorex administration on the activities of some enzymes of glycerolipid synthesis in rat liver and adipose tissue.

The Biochemical journal ·Vol. 166 ·No. 3 ·1977-09-15 ·Pages 639-42

Pritchard PH, Bowley M, Burditt SL, Cooling J, Glenny HP, Lawson N, Sturton RG, Brindley DN

Abstract

Rats were treated for 5 days with benfluorex [1-(3-trifluoromethylphenyl)-2-[N-(2-benzoyloxyethyl)amino]propane] or with suspending medium (controls). They were then intubated with an acute intoxicating dose of ethanol or with glucose of equivalent energy content. Treatment of the control rats with ethanol specifically increases the hepatic activity of the soluble phosphatidate phosphohydrolase by about 5-fold in 6 h. The equivalent increase for the benfluorex-treated rats were about 2-fold. The results are discussed in relation to the effects of ethanol and benfluorex on glycerolipid synthesis.

MeSH Terms

Adipose Tissue/enzymology Animals Ethanol/toxicity Fenfluramine/analogs & derivatives,toxicity Glucose/metabolism Glycerides/biosynthesis Glycolipids/biosynthesis Liver/enzymology Male Rats

Chemicals

Glycerides Glycolipids Fenfluramine Ethanol benfluorex Glucose

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Pritchard P H

Bowley M

Burditt S L

Cooling J

Glenny H P

Lawson N

Sturton R G

Brindley D N

References (32)

32 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1660639

Published

1977-09-15

Pages

639-42

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1165051

Subset

External Links

PubMed source DOI: 10.1042/bj1660639 PMC Full Text View journal details

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The effects of acute ethanol feeding and of chronic benfluorex administration on the activities of some enzymes of glycerolipid synthesis in rat liver and adipose tissue.

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