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PMID: 5780712 Published · ppublish English Journal Article

Radiation-induced breaks of DNA in cultured mammalian cells.

Biophysical journal ·Vol. 9 ·No. 3 ·1969-03-00 ·Pages 330-46

Veatch W, Okada S

Abstract

Mouse leukemic cells (L5178Y) in suspension culture were irradiated and the extent of single-strand breaks and double-strand cuts of DNA was estimated by sucrose gradient centrifugation. The radiation produced 3.0 single-strand breaks per cell (G(1) stage) per rad and approximately 0.3 double-strand breaks per cell (G(1) stage) per rad.

MeSH Terms
Animals Carbon Isotopes Centrifugation, Density Gradient Culture Techniques DNA, Neoplasm/radiation effects Hydrogen-Ion Concentration Leukemia, Experimental Mice Radiation Effects Thymidine/analysis Tritium Uridine
Chemicals
Carbon Isotopes DNA, Neoplasm Tritium Thymidine Uridine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Veatch W
Okada S
References (18)
18 references, click to expand
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(69)86390-3
Published
1969-03-00
Pages
330-46
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1367572
Subset
IM
External Links
PubMed source DOI: 10.1016/S0006-3495(69)86390-3 PMC Full Text View journal details
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