Miniature synaptic potentials at frog spinal neurones in the presence of tertodotoxin.

The Journal of physiology ·Vol. 199 ·No. 1 ·1968-11-00 ·Pages 205-21

Colomo F, Erulkar SD

Abstract

1. Spontaneous subthreshold potentials have been recorded with an intracellular electrode from neurones of the isolated spinal cord of the frog.2. Records of both depolarizing and hyperpolarizing potentials were obtained from cells in normal Ringer solution and also when impulse conduction in the cord had been abolished by tetrodotoxin (TTX).3. Comparisons of results before and after TTX show that the majority of the spontaneous potentials are analogous to miniature end-plate potentials.

MeSH Terms

Animals Anura Electric Conductivity Electrophysiology Evoked Potentials/drug effects Nerve Endings/physiology Neurons/physiology Spinal Cord/physiology Synapses/physiology Tetrodotoxin/pharmacology Time Factors

Chemicals

Tetrodotoxin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Colomo F

Erulkar S D

References (31)

31 references, click to expand

Origin of synaptic noise.
Science. 1967 Jul 21;157(3786):330-1 PMID: 6028406
Analysis of spontaneous subthreshold activity in spinal motoneurons of the cat.
J Neurophysiol. 1968 Mar;31(2):195-209 PMID: 4301172
Cortical intracellular potentials and their responses to strychnine.
J Neurophysiol. 1959 Jul;22(4):436-50 PMID: 13673295
Spontaneous subthreshold activity at mammalian neural muscular junctions.
J Physiol. 1956 Apr 27;132(1):61-73 PMID: 13320372
Calcium spikes of nerve cell membrane: role of calcium in the production of action potentials.
Nature. 1968 Feb 3;217(5127):468-9 PMID: 5641768
On the factors which determine the amplitude of the miniature end-plate potential.
J Physiol. 1957 Jul 11;137(2):267-78 PMID: 13449877
The action of tetrodotoxin on electrogenic components of squid giant axons.
J Gen Physiol. 1965 Jul;48(6):975-96 PMID: 5855512
A STUDY OF SPONTANEOUS MINIATURE POTENTIALS IN SPINAL MOTONEURONES.
J Physiol. 1963 Sep;168:389-422 PMID: 14062684
Spontaneous subthreshold activity at motor nerve endings.
J Physiol. 1952 May;117(1):109-28 PMID: 14946732
Some observations on biological noise.
Nature. 1950 Oct 7;166(4223):597-8 PMID: 14780165
Tetrodotoxin and neuromuscular transmission.
Proc R Soc Lond B Biol Sci. 1967 Jan 31;167(1006):8-22 PMID: 4382592
The mechanism of synaptic transmission.
Ergeb Physiol. 1961;51:299-430 PMID: 13889060
Spontaneous activity at a mammalian neuromuscular junction in tetrodotoxin.
Acta Physiol Scand. 1965 Aug;64(4):475-6 PMID: 5853040
The quantal nature of transmission and spontaneous miniature potentials at the crayfish neuromuscular junction.
J Physiol. 1961 Mar;155:514-29 PMID: 13724753
Release of acetylcholine from a nerve terminal by electric pulses of variable strength and duration.
Nature. 1965 Sep 4;207(5001):1097-8 PMID: 5866312
Slow membrane potential changes accompanying excitation and inhibition in spinal moto- and interneurons in the cat during natural activation.
Acta Physiol Scand. 1958 Oct 28;44(1):11-54 PMID: 13605806
Spontaneous synaptic potentials and quantal release of transmitter in the stellate ganglion of the squid.
J Physiol. 1967 Sep;192(2):379-406 PMID: 4383088
A study of synaptic transmission in the absence of nerve impulses.
J Physiol. 1967 Sep;192(2):407-36 PMID: 4383089
The recording of potentials from motoneurones with an intracellular electrode.
J Physiol. 1952 Aug;117(4):431-60 PMID: 12991232
The release of acetylcholine from nerve endings by graded electric pulses.
Proc R Soc Lond B Biol Sci. 1967 Jan 31;167(1006):23-38 PMID: 4382589
Effects of tetrodotoxin on the neuromuscular junction.
Jpn J Physiol. 1959 Jun 25;9(2):143-52 PMID: 13672686
Action of tetrodotoxin on spinal motoneurons of the cat.
J Neurophysiol. 1968 Mar;31(2):186-94 PMID: 4301171
The electrical activities of single motoneurones in toad's spinal cord, recorded with intracellular electrodes.
Jpn J Physiol. 1953 Dec 15;3(4):254-67 PMID: 13232850
TETRODOTOXIN BLOCKAGE OF SODIUM CONDUCTANCE INCREASE IN LOBSTER GIANT AXONS.
J Gen Physiol. 1964 May;47:965-74 PMID: 14155438
Spontaneous potential at sympathetic nerve endings in smooth muscle.
J Physiol. 1962 Mar;160:446-60 PMID: 13875001
Electrical properties and activities of single sympathetic neurons in frogs.
J Cell Comp Physiol. 1960 Feb;55:15-30 PMID: 14427308
Effects of strychnine on the intracellular potentials of spinal motoneurons of the toad.
Jpn J Physiol. 1957 Mar 15;7(1):42-50 PMID: 13491225
Stabilization and rectification of muscle fiber membrane by tetrodotoxin.
Am J Physiol. 1960 May;198:934-8 PMID: 14426011
Spontaneous synaptic activity in sympathetic ganglion cells of the frog.
J Physiol. 1963 Jul;167:389-401 PMID: 13971395
Electrophysiological investigations on Renshaw cells.
J Physiol. 1961 Dec;159:461-78 PMID: 13889049
Spontaneous potential changes at crayfish neuromuscular junctions.
Nature. 1960 May 7;186:476-7 PMID: 13818435

Article Info

Journal

The Journal of physiology

Abbr.

J Physiol

ISSN

0022-3751

DOI

10.1113/jphysiol.1968.sp008649

Published

1968-11-00

Pages

205-21

Language

English

Region

England

NLM ID

0266262

PMCID

PMC1365354

Subset

External Links

PubMed source DOI: 10.1113/jphysiol.1968.sp008649 PMC Full Text View journal details

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Miniature synaptic potentials at frog spinal neurones in the presence of tertodotoxin.

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