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PMID: 4383088 Published · ppublish English Journal Article

Spontaneous synaptic potentials and quantal release of transmitter in the stellate ganglion of the squid.

The Journal of physiology ·Vol. 192 ·No. 2 ·1967-09-00 ·Pages 379-406

Miledi R

Abstract

1. Several kinds of synapses have been studied in the stellate ganglion of the squid.2. A small electric coupling was found between giant fibres in different stellar nerves.3. Post-synaptic potentials recorded from the cells of small axons are composite, indicating that there are converging inputs from several pre-ganglionic fibres.4. Spontaneous miniature synaptic potentials were recorded from all types of synapses. Miniature potentials in the cells of small axons had a slower time course than those in the giant fibre system.5. Tetrodotoxin abolished nerve impulses in the ganglion but did not prevent the spontaneous quantal release of transmitter from the terminals, or its action on the post-synaptic membrane; nor did it prevent the increase in rate of release produced by depolarization of the presynaptic fibre.6. Glutamate depolarized the giant fibre when applied iontophoretically to the synaptic region. Similar doses applied intracellularly were without effect.

MeSH Terms
Action Potentials Animals Axons/drug effects,physiology Electric Stimulation Glutamates/pharmacology In Vitro Techniques Iontophoresis Mollusca Neuromuscular Junction/physiology Neurotransmitter Agents/metabolism Stellate Ganglion/physiology Synapses/physiology Synaptic Transmission Tetrodotoxin/pharmacology
Chemicals
Glutamates Neurotransmitter Agents Tetrodotoxin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Miledi R
References (34)
34 references, click to expand
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1967.sp008306
Published
1967-09-00
Pages
379-406
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1365563
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1967.sp008306 PMC Full Text View journal details
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