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PMID: 5535626 Published · ppublish English Journal Article

Delayed hypersensitivity-type granuloma formation and dermal reaction induced and elicited by a soluble factor isolated from Schistosoma mansoni eggs.

The Journal of experimental medicine ·Vol. 132 ·No. 3 ·1970-09-01 ·Pages 488-507

Boros DL, Warren KS

Abstract

A soluble material has been isolated from schistosome eggs which in minute quantities without the addition of adjuvant induces sensitization to a delayed hypersensitivity type of granuloma forming around intact schistosome eggs. This material is secreted by intact eggs and is found in high concentration in the fluid released during the hatching process. When adsorbed to bentonite particles this substance elicits hypersensitivity type granuloma formation in specifically sensitized animals. The granuloma sensitizing factor also both induces and elicits delayed footpad swelling in mice. Quantities which sensitize with respect to these delayed type reactions do not induce antibody formation detectable by a sensitive hemagglutination. technique within the duration of the above experiments.

MeSH Terms
Animals Antibody Formation Antigens Female Granuloma/immunology Hemagglutination Tests Hypersensitivity, Delayed Injections, Intravenous Lung/pathology Mice Ovum/immunology,metabolism Schistosoma mansoni/immunology Schistosomiasis/pathology Skin Diseases/immunology
Chemicals
Antigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Boros D L
Warren K S
References (30)
30 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.132.3.488
Published
1970-09-01
Pages
488-507
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2138804
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.132.3.488 PMC Full Text View journal details
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