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PMID: 546677 Published · ppublish English Journal Article

Genic heterogeneity within electrophoretic "alleles" and the pattern of variation among loci in Drosophila pseudoobscura.

Genetics ·Vol. 93 ·No. 4 ·1979-12-00 ·Pages 997-1018

Singh RS

Abstract

An investigation, similar to our previously reported xanthine dehydrogenase study, was undertaken to examine the extent of hidden genic variation at nine loci (five larval proteins, three esterases and one aldehyde oxidase) by sequential application of various electrophoretic criteria employing pH, gel concentration and buffer variation. Polymorphic loci appear to fall into two distinct groups: weakly polymorphic, including larval protein 6, 7, 8, 10 and 13 and esterase-1 and -6; and highly polymorphic, including esterase-5, Xdh and possibly Ao. Monomorphic loci may belong to a third group different from all polymorphic loci. Bogota, a geographical isolate that is reproductively isolated from the mainland population, was found to be genetically distinct at four of the ten loci examined in detail so far, including Xdh, whereas previously it was found to be genetically distinct at none. These results are discussed in the light of balancing selection, neutral and mutation-selection hypotheses of genic variation in natural populations.

MeSH Terms
Aldehyde Oxidoreductases/genetics Animals Drosophila/genetics Electrophoresis, Polyacrylamide Gel Esterases/genetics Genetic Variation Larva Proteins/genetics
Chemicals
Proteins Aldehyde Oxidoreductases Esterases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Singh R S
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39 references, click to expand
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/93.4.997
Published
1979-12-00
Pages
997-1018
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1214126
Subset
IM
External Links
PubMed source DOI: 10.1093/genetics/93.4.997 PMC Full Text View journal details
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