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PMID: 110315 Published · ppublish English Journal Article

Studies of esterase 6 in Drosophila melanogaster. I. The genetics of a posttranslational modification.

Biochemical genetics ·Vol. 17 ·No. 1-2 ·1979-02-00 ·Pages 167-83

Cochrane BJ, Richmond RC

Abstract

A locus has been found, an allele of which causes a modification of some allozymes of the enzyme esterase 6 in Drosophila melanogaster. There are two alleles of this locus, one of which is dominant to the other and results in increased electrophoretic mobility of affected allozymes. The locus responsible has been mapped to 3-56.7 on the standard genetic map (Est-6 is at 3-36.8). Of 13 other enzyme systems analyzed, only leucine aminopeptidase is affected by the modifier locus. Neuraminidase incubations of homogenates altered the electrophoretic mobility of esterase 6 allozymes, but the mobility differences found are not large enough to conclude that esterase 6 is sialylated.

MeSH Terms
Alleles Animals Chromosome Mapping Drosophila melanogaster/enzymology Esterases/genetics Genes Transcription, Genetic
Chemicals
Esterases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cochrane B J
Richmond R C
References (24)
24 references, click to expand
  1. Lack of genic similarity between two sibling species of drosophila as revealed by varied techniques.
    Genetics. 1976 Nov;84(3):593-607 PMID: 1001880
  2. Studies of a homologous gene-enzyme system, esterase C, in Drosophila melanogaster and Drosophila simulans.
    Biochem Genet. 1973 Apr;8(4):383-90 PMID: 4197378
  3. Neuraminidase; its substrate and mode of action.
    Adv Enzymol Relat Subj Biochem. 1958;20:135-46 PMID: 13605982
  4. Use of internal standards in electrophoretic surveys of enzyme polymorphism.
    Biochem Genet. 1975 Dec;13(11-12):833-47 PMID: 1200980
  5. Nongenetic heterogeneity of mouse beta-galactosidase.
    J Biol Chem. 1977 Jul 10;252(13):4613-8 PMID: 873909
  6. Starch gel electrophoresis in a discontinous system of buffers.
    Nature. 1957 Dec 28;180(4600):1477-9 PMID: 13493570
  7. Genetic heterogeneity within electrophoretic "alleles" of xanthine dehydrogenase in Drosophila pseudoobscura.
    Genetics. 1976 Nov;84(3):609-29 PMID: 1001881
  8. Inheritance of two alkaline phosphatase variants in fowl plasma.
    Science. 1965 Sep 24;149(3691):1518 PMID: 5828034
  9. Enzyme variability in the Drosophila willistoni group. 3. Amounts of variability in the superspecies, D. paulistorum.
    Genetics. 1972 Jan;70(1):87-112 PMID: 5013892
  10. Alkaline phosphatase and leucine aminopeptidase association in plasma of the chicken.
    Science. 1967 May 26;156(3778):1106-7 PMID: 6024189
  11. The Genetics of an Esterase in Drosophila Melanogaster.
    Genetics. 1963 Jun;48(6):787-801 PMID: 17248171
  12. The effect of neuraminidase on genetic variants of alpha anitrypsin.
    Am J Hum Genet. 1975 Mar;27(2):165-77 PMID: 1079112
  13. A gene apparently determining the extent of sialylation of lysosomal alpha-mannosidase in mouse liver.
    Biochem Genet. 1977 Feb;15(1-2):31-46 PMID: 849251
  14. Origin of alpha-glycerophosphate dehydrogenase isozymes in Drosophila melanogaster and their functional relationship in the alpha-glycerophosphate cycle.
    Biochem Genet. 1977 Apr;15(3-4):235-51 PMID: 405967
  15. STARCH-GEL ELECTROPHORESIS--APPLICATION TO THE CLASSIFICATION OF PITUITARY PROTEINS AND POLYPEPTIDES.
    Metabolism. 1964 Oct;13:SUPPL:985-1002 PMID: 14228777
  16. Protein kinases.
    Curr Top Cell Regul. 1972;5:99-133 PMID: 4358204
  17. Enzymatic interconversion of active and inactive forms of enzymes.
    Science. 1973 Apr 6;180(4081):25-32 PMID: 4144174
  18. Heat stability variants of esterase-6 in Drosophila melanogaster.
    Nature. 1976 Sep 9;263(5573):131-2 PMID: 823440
  19. Genic Heterogeneity at Two Alcohol Dehydrogenase Loci in DROSOPHILA PSEUDOOBSCURA and DROSOPHILA PERSIMILIS.
    Genetics. 1977 Oct;87(2):285-304 PMID: 17248763
  20. Posttranslational covalent modification of proteins.
    Science. 1977 Dec 2;198(4320):890-6 PMID: 337487
  21. Genetics and ontogeny of alpha-glycerophosphate dehydrogenase isozymes in Drosophila melanogaster.
    Biochem Genet. 1969 Aug;3(4):343-53 PMID: 5365510
  22. Hidden alleles at the alpha-glycerophosphate dehydrogenase locus in Colias butterflies.
    Genetics. 1976 May;83(1):149-67 PMID: 1269917
  23. A recessively inherited electrophoretic variant of alkaline phosphatase in chicken serum.
    Genetics. 1966 Apr;53(4):799-805 PMID: 5960262
  24. Analysis of bacteriophage T7 early RNAs and proteins on slab gels.
    J Mol Biol. 1973 Sep 15;79(2):237-48 PMID: 4760132
Article Info
Journal
Biochemical genetics
Abbr.
Biochem Genet
ISSN
0006-2928
DOI
10.1007/BF00484483
Published
1979-02-00
Pages
167-83
Language
English
Region
United States
NLM ID
0126611
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00484483 View journal details
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