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PMID: 5449120 Published · ppublish English Journal Article

The amino acid sequences of the Fd fragments of two human gamma-1 heavy chains.

The Biochemical journal ·Vol. 117 ·No. 4 ·1970-05-00 ·Pages 641-60

Press EM, Hogg NM

Abstract

The amino acid sequences of the Fd fragments of two human pathological immunoglobulins of the immunoglobulin G1 class are reported. Comparison of the two sequences shows that the heavy-chain variable regions are similar in length to those of the light chains. The existence of heavy chain variable region subgroups is also deduced, from a comparison of these two sequences with those of another gamma 1 chain, Eu, a mu chain, Ou, and the partial sequence of a fourth gamma 1 chain, Ste. Carbohydrate has been found to be linked to an aspartic acid residue in the variable region of one of the gamma 1 chains, Cor.

MeSH Terms
Amino Acid Sequence Aspartic Acid Binding Sites Carbohydrates Carbon Isotopes Chromatography, Gel Chymotrypsin Electrophoresis Heavy Chain Disease Humans Immunoglobulin G/analysis Trypsin
Chemicals
Carbohydrates Carbon Isotopes Immunoglobulin G Aspartic Acid Chymotrypsin Trypsin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Press E M
Hogg N M
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24 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1170641
Published
1970-05-00
Pages
641-60
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1179015
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1170641 PMC Full Text View journal details
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