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PMID: 5461106 Published · ppublish English Journal Article

Sequence studies of the Fd section of the heavy chain of rabbit immunoglobulin G.

The Biochemical journal ·Vol. 116 ·No. 2 ·1970-01-00 ·Pages 249-59

Fruchter RG, Jackson SA, Mole LE, Porter RR

Abstract

A partial amino acid sequence was given by Cebra, Steiner & Porter (1968b) of the N-terminal half of the heavy chain of rabbit immunoglobulin G. This was extended and in part corrected to give a continuous sequence of 136 residues, which together with other work accounts for three-quarters of the total sequence. Evidence is given suggesting that there is a limited region of 10-15 residues that are exceptionally variable in the heavy chains from pooled rabbit immunoglobulin G.

MeSH Terms
Amino Acid Sequence Animals Chromatography Chymotrypsin Immunoglobulin G/analysis Peptides/analysis Rabbits Trypsin
Chemicals
Immunoglobulin G Peptides Chymotrypsin Trypsin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Fruchter R G
Jackson S A
Mole L E
Porter R R
References (9)
9 references, click to expand
  1. Disulphide bridges of immunoglobin G-1 heavy chains.
    Nature. 1967 Dec 2;216(5118):939-41 PMID: 4169396
  2. The amino acid sequence of the Fc fragment of rabbit immunoglobulin G. I. The isolation and amino acid composition of tryptic peptides.
    J Biol Chem. 1968 Aug 25;243(16):4197-205 PMID: 4176008
  3. Variation in the N-terminal sequence of heavy chains of immunoglobulin G from rabbits of different allotype.
    Biochem J. 1969 Apr;112(2):173-85 PMID: 4895565
  4. Combinations of specific color reactions useful in the peptide mapping technique.
    Biochim Biophys Acta. 1965 Sep 13;107(2):386-8 PMID: 5880562
  5. The basic sequences of immunoglobulin kappa chains: Sequence studies of bence jones proteins Rad, Fr 4 and B6.
    FEBS Lett. 1969 Mar;2(5):301-304 PMID: 11946339
  6. Allotype-related sequence variation of the heavy chain of rabbit immunoglobulin G.
    Biochem J. 1968 May;107(6):753-63 PMID: 16742601
  7. Reversible blocking of peptide amino groups by maleic anhydride.
    Biochem J. 1967 Jun;103(3):78P-79P PMID: 6049401
  8. Common peptides from the N-terminal half of heavy chain of immunoglobulin G from normal rabbit serum and a specific antibody.
    Biochem J. 1968 Mar;107(1):69-77 PMID: 4171077
  9. The disulphide bonds of the heavy chain of rabbit immunoglobulin G.
    Biochem J. 1970 Jan;116(2):261-8 PMID: 5461107
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
Published
1970-01-00
Pages
249-59
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1185353
Subset
IM
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