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PMID: 53257 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies.

The Journal of experimental medicine ·Vol. 142 ·No. 5 ·1975-11-01 ·Pages 1121-32

Trenkner E, Riblet R

Abstract

Anti-idiotypic antibodies have been used to mimic antigen in the mouse antiphosphorylcholine response in order to investigate the induction of precursors of antibody-forming cells. We have shown that interaction of anti-idiotype antibody with receptor antibody molecules induces the formation of antibodies that are specific for phosphorylcholine and carry the idiotypic determinants. This induction is dependent on the recognition of carrier determinants on the anti-idiotype antibody by helper T cells. We conclude that receptor antibody molecules on the surface of the precursors of antibody-forming cells deliver the antigenic signal for the induction of these cells.

MeSH Terms
Animals Antibodies, Anti-Idiotypic Antibody Formation Antibody Specificity Antibody-Producing Cells/immunology Binding Sites, Antibody Cells, Cultured Choline/analogs & derivatives Epitopes Immunoglobulins/immunology Mice Mice, Inbred Strains Phosphorylcholine/immunology Spleen/immunology T-Lymphocytes/immunology
Chemicals
Antibodies, Anti-Idiotypic Epitopes Immunoglobulins Phosphorylcholine Choline
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Trenkner E
Riblet R
References (21)
21 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.142.5.1121
Published
1975-11-01
Pages
1121-32
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2189971
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.142.5.1121 PMC Full Text View journal details
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