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PMID: 5318739 Published · ppublish English Journal Article Review

Biological activities of pure prostaglandins.

Experientia ·Vol. 21 ·No. 3 ·1965-03-15 ·Pages 113-8

Horton EW

Abstract

暂无摘要

Keywords
Animals Laboratory Biology Cardiovascular Effects Central Nervous System Effects Clinical Research Endocrine System Literature Review Physiology Prostaglandins Reproduction Research Methodology
MeSH Terms
Animals In Vitro Techniques Physiology Prostaglandins/pharmacology
Chemicals
Prostaglandins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Horton E W
Other Abstracts
eng

Prostaglandins, the hydroxy unsaturated C20 fatty acids, are found throughout the body and have an equally wide range of biological activities. Prostaglandins are known to: 1) stimulate uterine contraction

2) inhibit spontaneous contraction of the rabbit uterus

3) inhibit the respiratory smooth muscle of different animals

4) lower systemic arterial blood pressure when injected intravenously

5) stimulate contractions in isolateral segments of intestinal smooth muscle of most species investigated

6) produce transient sedation when intravenously injected in cats, and 7) inhibit lipolysis induced by catechal amines, corticotrophin, glucagon and thyroid stimulating hormone. The inhibitory and excitatory effects of prostaglandins may each have a physiological importance at different sites. Current state of knowledge of the distribution, metabolism and actions of the prostaglandins is still fragmentary. The functional significance of the prostaglandins is yet to be determined.

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Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF02141963
Published
1965-03-15
Pages
113-8
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02141963
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