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PMID: 5309453 Published · ppublish English Journal Article

Immunological relationships between the neuraminidases of human and animal influenza viruses.

Bulletin of the World Health Organization ·Vol. 41 ·No. 3 ·1969-00-00 ·Pages 437-45

Schild GC, Newman RW

Abstract

The neuraminidases of 3 human A2 virus strains-A2/Singapore/1/57, A2/England/76/66 and A2/Hong Kong/1/68-were compared immunologically with those of a number of influenza A virus strains of animal origin (14 avian, 2 equine and 1 porcine). The methods used were enzyme-inhibition tests and immuno-double-diffusion. In enzyme-inhibition tests, the neuraminidases of the A2/57 and A2/66 viruses cross-reacted with those of Turkey/Wisconsin/66, Turkey/Massachusetts/65 and Duck/Italy/574/66 viruses. The enzyme of the Hong Kong variant had a wider spectrum of cross-reactions than did those of the A2/57 and A2/66 viruses. No cross-reaction was detected with Turkey/Massachusetts/65 but the A2/Hong Kong enzyme showed major antigenic similarities with the enzymes of Turkey/Wisconsin/66 and Duck/Italy/574/66 and Duck/Germany/1998/68 viruses. Minor cross-reactions were also detected between the A2/Hong Kong enzyme and those of fowl plague virus, virus "N", Duck/England/56 and Swine/Cambridge/39.The cross-reactions between the enzymes of A2/Hong Kong and Turkey/Wisconsin/66 were confirmed by immunoprecipitin tests. Those between A2/Hong Kong and fowl plague virus, virus "N", Duck/England/56 and Swine/Cambridge/39 could not be confirmed by immunoprecipitation.The finding of antigenic similarities between the enzymes of human and avian influenza A viruses may be of importance in considering the origin of the new antigenic variants of influenza A virus which appear in man.

MeSH Terms
Animals Antigen-Antibody Reactions Birds Cross Reactions Genetic Variation Horses Humans Neuraminidase Orthomyxoviridae/immunology Swine
Chemicals
Neuraminidase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schild G C
Newman R W
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17 references, click to expand
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Article Info
Journal
Bulletin of the World Health Organization
Abbr.
Bull World Health Organ
ISSN
0042-9686
Published
1969-00-00
Pages
437-45
Language
English
Region
Switzerland
NLM ID
7507052
PMCID
PMC2427742
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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