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PMID: 5302333 Published · ppublish English Journal Article

Antigenic relationship between influenza A viruses of human and animal origin.

Bulletin of the World Health Organization ·Vol. 38 ·No. 3 ·1968-00-00 ·Pages 415-20

Tůmová B, Pereira HG

Abstract

Reciprocal antigenic relationships between 17 influenza A viruses of human, porcine, equine and avian origin were investigated by haemagglutination-inhibition (HI) and strain-specific complement-fixation (CF). Cross-reactions were observed between the following strains: (a) Equi/1/Prague/1/56, Fowl plague (Dutch strain) and Turkey/England/1/63 (Langham strain); (b) Equi/2/Miami/1/63, Quail/Italy/1117/65, Pheasant/Italy/647/66, Duck/England/1/62 and Turkey/Canada/1/63; (c) A2/Singapore/1/57 and Turkey/Massachussets/65; (d) Swine/S15/30 and Chicken/Scotland/1/59. The results of HI tests performed with post-infection sera showed on the whole narrower specificity than those of HI with hyperimmune sera or those of strain-specific CF. There is clearly no sharp demarcation of antigenic subtypes of influenza A viruses, and studies over a yet wider range of strains are likely to disclose a continuous spectrum of antigenic variation for the whole group. The authors suggest that, in practice, host specificity rather than antigenic specificity may have to be used as the main criterion in classifying influenza A viruses.

MeSH Terms
Antigens Complement Fixation Tests Hemagglutination Inhibition Tests Humans Orthomyxoviridae/classification,immunology Serotyping Species Specificity
Chemicals
Antigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tůmová B
Pereira H G
References (24)
24 references, click to expand
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Article Info
Journal
Bulletin of the World Health Organization
Abbr.
Bull World Health Organ
ISSN
0042-9686
Published
1968-00-00
Pages
415-20
Language
English
Region
Switzerland
NLM ID
7507052
PMCID
PMC2554487
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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