The Ah locus: biochemical basis for genetic differences in brain tumor formation in mice.

Genetics ·Vol. 92 ·No. 4 ·1979-08-00 ·Pages 1205-10

Levitt RC, Fysh JM, Jensen NM, Nebert DW

Abstract

Allelic differences at the Ah locus are showen to exist in the mouse brain. This finding probably explains inbred mouse strain differences in polycyclic hydrocarbon tumorigenesis of the brain described more than 35 years ago and may be important in understanding the etiology of genetic differences in certain human intracranial neoplasms.

MeSH Terms

Alleles Animals Aryl Hydrocarbon Hydroxylases/biosynthesis,genetics Brain Neoplasms/chemically induced,genetics Chromosome Mapping Cytochrome P-450 Enzyme System/biosynthesis,genetics Enzyme Induction Genes Male Methylcholanthrene Mice Mice, Inbred Strains/genetics Neoplasms, Experimental/chemically induced,genetics

Chemicals

Methylcholanthrene Cytochrome P-450 Enzyme System Aryl Hydrocarbon Hydroxylases

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Levitt R C

Fysh J M

Jensen N M

Nebert D W

References (9)

9 references, click to expand

Protein measurement with the Folin phenol reagent.
J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain.
J Exp Med. 1977 Jun 1;145(6):1607-11 PMID: 194012
Cytochrome P-450 and NADPH cytochrome c reductase in rat brain: formation of catechols and reactive catechol metabolites.
Biochem Biophys Res Commun. 1977 Oct 10;78(3):919-26 PMID: 410418
Pharmacogenetics: a possible pragmatic perspective in neoplasm predictability.
Semin Oncol. 1978 Mar;5(1):89-106 PMID: 345457
Genetic differences in microsomal electron transport: the Ah locus.
Methods Enzymol. 1978;52:226-40 PMID: 672631
Effect of charcoal-broiled beef on phenacetin metabolism in man.
Science. 1976 Dec 3;194(4269):1055-7 PMID: 982059
Differences in inducibility of cutaneous and hepatic drug metabolizing enzymes and cytochrome P-450 by polychlorinated biphenyls and 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT).
J Pharmacol Exp Ther. 1974 Feb;188(2):300-9 PMID: 4204348
Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a potent inducer of aryl hydrocarbon hydroxylase, with 3-methylcholanthrene.
Mol Pharmacol. 1974 Mar;10(2):349-59 PMID: 4851117
Induction and suppression of hepatic and extrahepatic microsomal foreign-compound-metabolizing enzyme systems by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Chem Biol Interact. 1975 Mar;10(3):199-214 PMID: 805004

Article Info

Journal

Genetics

Abbr.

Genetics

ISSN

0016-6731

DOI

10.1093/genetics/92.4.1205

Published

1979-08-00

Pages

1205-10

Language

English

Region

United States

NLM ID

0374636

PMCID

PMC1214065

Subset

External Links

PubMed source DOI: 10.1093/genetics/92.4.1205 PMC Full Text View journal details

Analysis Services

The Ah locus: biochemical basis for genetic differences in brain tumor formation in mice.

Contact

WeChat Official Account